Sebelipase alfa, sold under the brand name Kanuma, is a recombinant form of the enzyme lysosomal acid lipase (LAL) that is used as a medication for the treatment of lysosomal acid lipase deficiency (LAL-D).[6][7] It is administered via intraveneous infusion.[5] It was approved for medical use in the European Union and in the United States in 2015.[8][6][5][7]
Sebelipase alfa is indicated for long-term enzyme replacement therapy (ERT) in people of all ages with lysosomal acid lipase (LAL) deficiency.[6]
Sebelipase was developed by Synageva that became part of Alexion Pharmaceuticals in 2015. For its production, chickens are genetically modified to produce the recombinant form of LAL (rhLAL) in their egg white. After extraction and purification it becomes available as the medication.[9] On 8 December 2015 the FDA announced that its approval came from two centers: The Center for Drug Evaluation and Research (CDER) approved the human therapeutic application of the medication, while the Center for Veterinary Medicine (CVM) approved the application for a recombinant DNA construct in genetically engineered chicken to produce rhLAL in their egg whites.[10] At the time it gained FDA approval Kanuma was the first only drug manufactured in chicken eggs and intended for use in humans.[9]
Sebelipase alfa is an orphan drug; its effectiveness was published after a phase 3 trial in 2015.[11] The disease of LAL affects < 0.2 in 10,000 people in the EU.[8]
Serangan Dnieper HilirBagian dari Front Timur dari Perang Dunia IIPara prajurit Soviet sedang melintasi DnieperTanggal24 August 1943 — 23 Desember 1943LokasiSungai Dnieper, Uni SovietHasil Kemenangan SovietPerubahanwilayah Soviet mengklaim kembali tepi kiri Ukraina, termasuk kota Kiev dan cekungan DonetsPihak terlibat Uni Soviet Brigade Independen Cekoslowakia Germany RumaniaTokoh dan pemimpin Georgy Zhukov Aleksandr Vasilevsky Nikolai Vatutin Ivan Konev Rodion Malinovsky Fyodor To…
Embajada del Reino de España en la República Islámica de Pakistán Logotipo del MinisterioLocalizaciónPaís PakistánLocalidad IslamabadCoordenadas 33°43′22″N 73°06′18″E / 33.7227, 73.105Información generalJurisdicción Pakistán PakistánTipo EmbajadaSede Street 6, Ramna 5. Diplomatic Enclave I. P.O. Box 1144, Islamabad.OrganizaciónMinistros Manuel Durán Giménez-Rico (embajador)Dependencias Consulados honorarios en Lahore y Karachi.HistoriaFundación 1952 …
SentangKelurahanKantor Kelurahan SentangNegara IndonesiaProvinsiSumatera UtaraKabupatenAsahanKecamatanKota Kisaran TimurKodepos21224Kode Kemendagri12.09.20.1004 Kode BPS1208170001 Luas... km²Jumlah penduduk... jiwaKepadatan... jiwa/km² Sentang merupakan salah satu kelurahan yang ada di kecamatan Kota Kisaran Timur, Kabupaten Asahan, provinsi Sumatera Utara, Indonesia. lbsKecamatan Kota Kisaran Timur, Kabupaten Asahan, Sumatera UtaraKelurahan Gambir Baru Karang Anyer Kedai Ledang Kisaran N…
Marie Liljedahl Información personalNacimiento 15 de febrero de 1950 (73 años)Estocolmo (Suecia) Nacionalidad SuecaInformación profesionalOcupación Actriz [editar datos en Wikidata] Marie Liljedahl (Estocolmo, 15 de febrero de 1950) es una actriz sueca que tuvo una breve carrera cinematográfica a fines de la década de 1960 y principios de la de 1970, en las películas de Joseph W. Sarno y Jesús Franco. Biografía Nacida en Estocolmo, Suecia, Liljedahl se convirtió en actriz de …
Kereta bawah tanah TorontoInfoPemilik Pemerintah kota Toronto (Jalur 1, 2, 3 dan 4) Metrolinx (Jalur 5 dan 6) Wilayah Toronto Vaughan JenisAngkutan cepatJumlah jalur4 (ditambah 2 dalam pembangunan)Jumlah stasiun75 [1][2]Penumpang harian1.58 juta (avg. unlinked weekday, Q1 2019)[3]Penumpang tahunan216.7 juta (2018)[4]Situs webwww.ttc.ca/Subway/OperasiDimulai30 Maret 1954OperatorToronto Transit Commission (TTC)Jumlah gerbong 858 kereta api berat dan mobil …
У Вікіпедії є статті про інших людей із прізвищем Хомишин. Блаженний ГригорійГригорій Лукич Хомишин Єпископ Григорій Хомишин Альма-матер: Віденський університет і Авґустинеум Діяльність: політик, католицький священник, письменник, католицький єпископ Нар
El deshielo de Jrushchov o el deshielo en la Unión Soviética (ruso: хрущёвская о́ттепель (xru ɕ ɕovskəjа ˈotʲɪpʲеlʲ[1]), transliterado como jrushchóvskaya óttepel o simplemente óttepel) se refiere al período entre 1956 y 1964 en la Unión Soviética, en el que la represión política y la censura fueron parcialmente relajadas debido a las políticas de desestalinización implementadas por el entonces nuevo líder soviético Nikita Jrushchov. Una de las c…
كوم البركة - قرية مصرية - تقسيم إداري البلد مصر المحافظة محافظة البحيرة المركز كفر الدوار المسؤولون السكان التعداد السكاني 20349 نسمة (إحصاء 2006) معلومات أخرى التوقيت ت ع م+02:00 تعديل مصدري - تعديل قرية كوم البركة هي إحدى القرى التابعة لمركز كفر الدوار في محا
Герб Новоайдарського району ДеталіНосій Новоайдарський районЩит Німецький щитОснова Жовто-червоно-блакитний щитІнші елементи Соняшник, сом, козаки Герб Новоайда́рського району — офіційний символ Новоайдарського району Луганської області. Зміст 1 Опис 2 Символіка 3 Д…
Liste officielle, en date du 28 décembre 2019, des 433 stations de tourisme françaises désignées par décret ministériel pour une durée de douze ans[1]. Il existe au départ une seule catégorie de classement pour les stations de curistes. À la fin des années 1910, il est possible de faire classer la commune comme station hydrominérale et climatique, hydrominérale ou climatique. Une catégorie station de tourisme est créée ensuite, ainsi que la catégorie uvale ; les catég…
Ribut Hari WibowoKarobinkar SSDM Polri Informasi pribadiLahir30 Juli 1974 (umur 49)Magetan, Jawa TimurAlma materAkademi Kepolisian (1996)Karier militerPihak IndonesiaDinas/cabang Kepolisian Negara Republik IndonesiaMasa dinas1996—sekarangPangkat Brigadir Jenderal PolisiNRP74070746SatuanReserseSunting kotak info • L • B Brigjen. Pol. Ribut Hari Wibowo, S.H., S.I.K. (lahir 30 Juli 1974) adalah seorang perwira tinggi Polri yang sejak 17 Desember 2021 menjabat sebagai …
This article relies largely or entirely on a single source. Relevant discussion may be found on the talk page. Please help improve this article by introducing citations to additional sources.Find sources: Break Up 100 – news · newspapers · books · scholar · JSTOR (October 2014) 2014 Hong Kong filmBreak Up 100Directed byLawrence ChengStarringEkin ChengChrissie ChauIvana WongRelease date 1 August 2014 (2014-08-01) CountryHong KongBox officeHK…
Batalyon Artileri Medan 7/Biring GalihLambang Yon Armed 7/105 GS/Biring GalihDibentuk15 Februari 1977NegaraIndonesiaCabangArmedTipe unitSatuan Bantuan TempurPeranPasukan Artileri DaratBagian dariKodam JayaMarkasKota Bekasi, Jawa BaratJulukanYon Armed 7/105 GS/BGMotoDure Catru WinasenaBaretCoklatMaskotTombak Sakti Pangeran JayakartaUlang tahun15 FebruariAlutsistaAMX MK-61 105mm dan M109 A4 155mm Batalyon Artileri Medan 7/Biring Galih atau Yon Armed 7/105/Gerak Sendiri adalah merupakan batalyon Ar…
Usus dua belas jariDiagram usus dua belas jari (terlabel gastrointestinal tract)PengidentifikasiMeSHD004386TA98A05.6.02.001TA22944FMA7206Daftar istilah anatomi[sunting di Wikidata] Usus dua belas jari (bahasa Inggris: duodenum) adalah bagian dari usus halus yang terletak setelah lambung dan menghubungkannya ke usus kosong (jejunum) dengan panjang antara 25–38 cm. Bagian usus dua belas jari merupakan bagian terpendek dari usus halus, dimulai dari bulbo duodenale dan berakhir di lig…
Song by Hal David and Albert Hammond This article is about the song. For the episode of Cheers, see List of Cheers episodes § ep138. To All the Girls I've Loved BeforeSingle by Julio Iglesias and Willie Nelsonfrom the album 1100 Bel Air Place B-sideI Don't Want to Wake YouReleasedFebruary 1984Recorded1983GenreCountry pop[1]Length3:30LabelColumbiaSongwriter(s)Albert Hammond and Hal DavidProducer(s)Richard PerryJulio Iglesias singles chronology The Air That I Breathe (1983) To Al…
Political movement between 1808 and 1812 This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Carlotism – news · newspapers · books · scholar · JSTOR (October 2021) (Learn how and when to remove this template message) Carlotism was a political movement that took place in the Viceroyalty of the Río de la Plata betwe…
У Вікіпедії є статті про інші значення цього терміна: Кленове. село Кленове Країна Україна Область Харківська область Район Богодухівський район Громада Богодухівська міська громада Код КАТОТТГ UA63020010240049722 Облікова картка Кленове Основні дані Засноване 1804 Населен…
Wappen Deutschlandkarte 48.0716666666679.1755555555556630Koordinaten: 48° 4′ N, 9° 11′ O Basisdaten Bundesland: Baden-Württemberg Regierungsbezirk: Tübingen Landkreis: Sigmaringen Höhe: 630 m ü. NHN Fläche: 28,73 km2 Einwohner: 2975 (31. Dez. 2022)[1] Bevölkerungsdichte: 104 Einwohner je km2 Postleitzahl: 72514 Vorwahl: 07571 Kfz-Kennzeichen: SIG, SLG, STO, ÜB Gemeindeschlüssel: 08 4 37 059 Gemeindeglieder…
Metropolis in Kerala, India This article is about the city. For the district, see Kozhikode District. For the medieval kingdom of the Town of Calicut, see Kozhikode (disambiguation). Not to be confused with Kolkata. Metropolis in Kerala, IndiaKozhikode CalicutMetropolis From top: Kozhikode Beach, Kakkayam Valley, IIM Kozhikode, Calicut mini bypass, KSRTC bus stand complex, Hilite Mall, Chaliyam harbour, Calicut beach skyline.Nickname(s): City of Spices[1] (Other nicknames include Ci…
This article is about the Australian federal electorate. For other uses, see Electoral district of Brisbane. Australian federal electoral division BrisbaneAustralian House of Representatives DivisionDivision of Brisbane in Queensland, as of the 2019 federal electionCreated1901MPStephen BatesPartyGreensNamesakeBrisbaneElectors125,241 (2022)Area57 km2 (22.0 sq mi)DemographicInner metropolitan The Division of Brisbane is an Australian electoral division in the state of Queenslan…
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