SNX6

sorting nexin 6
Identifiers
SymbolSNX6
NCBI gene58533
HGNC14970
OMIM606098
RefSeqNM_021249
UniProtQ9UNH7
Other data
LocusChr. 14 q13
Search for
StructuresSwiss-model
DomainsInterPro

Sorting Nexin 6 also known as SNX6 is a well-conserved membrane-associated protein belonging to the sorting nexin family that is a component of the retromer complex.[1] The protein contains a coiled-coil domain at its C terminus and a PX domain at its N terminus. Binding to PIM1 causes translocation to the nucleus.[2] SNX6 has been shown to associate with TRAF4.[3]

References

  1. ^ Wassmer T, Attar N, Bujny MV, Oakley J, Traer CJ, Cullen PJ (January 2007). "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer". J. Cell Sci. 120 (Pt 1): 45–54. doi:10.1242/jcs.03302. PMID 17148574.
  2. ^ Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ (June 2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
  3. ^ Ishibashi Y, Maita H, Yano M, Koike N, Tamai K, Ariga H, Iguchi-Ariga SM (September 2001). "Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus". FEBS Lett. 506 (1): 33–8. doi:10.1016/S0014-5793(01)02881-2. PMID 11591366.


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