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SNX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I4K, 4FZS
Identifiers
Aliases	SNX1, HsT17379, VPS5, sorting nexin 1
External IDs	OMIM: 601272; MGI: 1928395; HomoloGene: 99716; GeneCards: SNX1; OMA:SNX1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,146,090 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	66,033,869 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; monocyte; ; upper lobe of left lung; ; ectocervix; ; C1 segment; ; left adrenal cortex;
	Top expressed in
	spermatocyte; ; gastrula; ; spermatid; ; decidua; ; blastocyst; ; saccule; ; morula; ; yolk sac; ; lens; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; insulin receptor binding; leptin receptor binding; epidermal growth factor receptor binding; protein binding; phosphatidylinositol binding; identical protein binding; protein heterodimerization activity; transferrin receptor binding; lipid binding; cadherin binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; cell projection; early endosome membrane; membrane; retromer, tubulation complex; intracellular membrane-bounded organelle; retromer complex; early endosome; endosome membrane; lamellipodium; extrinsic component of membrane; vesicle; lysosome; endosome; protein-containing complex;
Biological process	positive regulation of protein catabolic process; vesicle organization; early endosome to Golgi transport; receptor internalization; endosomal transport; retrograde transport, endosome to Golgi; protein transport; intracellular protein transport; lamellipodium morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6642
	56440
	ENSG00000028528
	ENSMUSG00000032382
	Q13596
	Q9WV80
	NM_001242933; NM_003099; NM_148955; NM_152826
	NM_019727
	NP_001229862; NP_003090; NP_683758
	NP_062701
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin.^[5] SNX1 is a component of the retromer complex.^[6]^[7]

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000028528 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032382 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kurten RC, Cadena DL, Gill GN (May 1996). "Enhanced degradation of EGF receptors by a sorting nexin, SNX1". Science. 272 (5264): 1008–10. Bibcode:1996Sci...272.1008K. doi:10.1126/science.272.5264.1008. PMID 8638121. S2CID 42608043.
^ Vergés M (2008). Retromer: multipurpose sorting and specialization in polarized transport. International Review of Cell and Molecular Biology. Vol. 271. pp. 153–98. doi:10.1016/S1937-6448(08)01204-5. ISBN 9780123747280. PMID 19081543. {{cite book}}: |journal= ignored (help)
^ Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi:10.1016/j.ceb.2008.03.009. PMC 2833274. PMID 18472259.
^ "Entrez Gene: sorting nexin 1".