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SNX5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SYS
Identifiers
Aliases	SNX5, sorting nexin 5
External IDs	OMIM: 605937; MGI: 1916428; HomoloGene: 40944; GeneCards: SNX5; OMA:SNX5 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	17,968,980 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	144,112,826 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; ventricular zone; ; Achilles tendon; ; rectum; ; gonad; ; spleen; ; corpus epididymis; ; secondary oocyte; ; left ovary;
	Top expressed in
	stroma of bone marrow; ; tail of embryo; ; abdominal wall; ; epiblast; ; Gonadal ridge; ; mandibular prominence; ; dermis; ; efferent ductule; ; migratory enteric neural crest cell; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dynactin binding; protein binding; phosphatidylinositol binding; protein heterodimerization activity; lipid binding; cadherin binding; phosphatidylinositol-5-phosphate binding; D1 dopamine receptor binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding;
Cellular component	cytoplasm; endosome; cell projection; early endosome membrane; retromer, tubulation complex; membrane; ruffle; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; extrinsic component of endosome membrane; tubular endosome; retromer complex; early endosome; phagocytic cup; cytoplasmic vesicle membrane; macropinocytic cup; cytoplasmic vesicle; cytosol; brush border; intracellular anatomical structure;
Biological process	endocytosis; vesicle organization; retrograde transport, endosome to Golgi; protein transport; pinocytosis; intracellular protein transport; regulation of macroautophagy; epidermal growth factor catabolic process; positive regulation of renal sodium excretion; negative regulation of blood pressure;
	Sources:Amigo / QuickGO
Orthologs
	27131
	69178
	ENSG00000089006
	ENSMUSG00000027423
	Q9Y5X3; Q5QPE4
	Q9D8U8
	NM_152227; NM_001282454; NM_014426
	NM_001199188; NM_024225
	NP_001269383; NP_055241; NP_689413
	NP_001186117; NP_077187
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.^[5]^[6]^[7]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex,^[6] which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.^[7]

Interactions

SNX5 has been shown to interact with FANCA.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089006 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027423 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Otsuki T; Kajigaya S; Ozawa K; Liu JM (Jan 2000). "SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein". Biochem Biophys Res Commun. 265 (3): 630–5. doi:10.1006/bbrc.1999.1731. PMID 10600472.
^ ^a ^b Wassmer T; Attar N; Bujny MV; Oakley J; Traer CJ; Cullen PJ (Dec 2006). "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer". J Cell Sci. 120 (Pt 1): 45–54. doi:10.1242/jcs.03302. PMID 17148574.
^ ^a ^b "Entrez Gene: SNX5 sorting nexin 5".

Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Towler MC, Gleeson PA, Hoshino S, et al. (2005). "Clathrin Isoform CHC22, a Component of Neuromuscular and Myotendinous Junctions, Binds Sorting Nexin 5 and Has Increased Expression during Myogenesis and Muscle Regeneration". Mol. Biol. Cell. 15 (7): 3181–95. doi:10.1091/mbc.E04-03-0249. PMC 452575. PMID 15133132.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Merino-Trigo A, Kerr MC, Houghton F, et al. (2005). "Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation". J. Cell Sci. 117 (Pt 26): 6413–24. doi:10.1242/jcs.01561. PMID 15561769. S2CID 39278533.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089006 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027423 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10600472-5] Otsuki T; Kajigaya S; Ozawa K; Liu JM (Jan 2000). "SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein". Biochem Biophys Res Commun. 265 (3): 630–5. doi:10.1006/bbrc.1999.1731. PMID 10600472.

[pmid17148574-6] Wassmer T; Attar N; Bujny MV; Oakley J; Traer CJ; Cullen PJ (Dec 2006). "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer". J Cell Sci. 120 (Pt 1): 45–54. doi:10.1242/jcs.03302. PMID 17148574.

[entrez-7] "Entrez Gene: SNX5 sorting nexin 5".

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SNX5

Interactions

References

Further reading