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SL88.0338

SL88.0338
Clinical data
Drug classSerotonin 5-HT1A receptor antagonist
ATC code
  • None
Identifiers
  • [4-[(5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]piperidin-1-yl]-(3-ethoxyphenyl)methanone
PubChem CID
ChemSpider
Chemical and physical data
FormulaC26H34N2O4
Molar mass438.568 g·mol−1
3D model (JSmol)
  • CCOC1=CC=CC(=C1)C(=O)N2CCC(CC2)CN3CCC4=C(C=CC(=C4C3)OC)OC
  • InChI=1S/C26H34N2O4/c1-4-32-21-7-5-6-20(16-21)26(29)28-14-10-19(11-15-28)17-27-13-12-22-23(18-27)25(31-3)9-8-24(22)30-2/h5-9,16,19H,4,10-15,17-18H2,1-3H3
  • Key:UUKBVYPABSDKFF-UHFFFAOYSA-N

SL88.0338 is a serotonergic drug with a benzoylpiperidine structure, which is used in scientific research. It acts as a potent and selective 5-HT1A receptor antagonist. It is used for basic research into the action and behavioural effects of 5-HT1A receptor activation and inactivation.[1][2][3][4]

See also

References

  1. ^ Griebel G, Rodgers RJ, Perrault G, Sanger DJ (May 1999). "Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists". Psychopharmacology. 144 (2): 121–130. doi:10.1007/s002130050984. PMID 10394992.
  2. ^ Griebel G, Rodgers RJ, Perrault G, Sanger DJ (July 2000). "The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety". Neuropharmacology. 39 (10): 1848–1857. doi:10.1016/s0028-3908(00)00074-5. PMID 10884565.
  3. ^ Depoortere R, Boulay D, Perrault G, Bergis O, Decobert M, Françon D, et al. (November 2003). "SSR181507, a dopamine D2 receptor antagonist and 5-HT1A receptor agonist. II: Behavioral profile predictive of an atypical antipsychotic activity". Neuropsychopharmacology. 28 (11): 1889–1902. doi:10.1038/sj.npp.1300261. PMID 12902993.
  4. ^ Boulay D, Depoortere R, Louis C, Lacave M, Lucas MT, Griebel G (January 2011). "SSR181507, a dopamine D₂ receptor and 5-HT(₁A) receptor ligand: evidence for mixed anxiolytic- and antidepressant-like activities". Pharmacology, Biochemistry, and Behavior. 97 (3): 428–435. doi:10.1016/j.pbb.2010.09.019. PMID 20920519.
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