Proton-gated urea channel

Acid-activated urea/amide channel
Urea channel hexamer (side view) from Helicobacter pylori
Identifiers
SymbolUAC
PfamPF02293
TCDB1.A.29
OPM superfamily299
OPM protein3ux4
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The proton-gated urea channel is an inner-membrane protein essential for the survival to Helicobacter pylori. It enables the rapid influx of urea into the bacterium. It is closed at pH 7.0 and fully open at pH 5.0. Urease activity buffers the periplasm to pH 6.1. Using multiwavelength anomalous dispersion (MAD), its structure, a compact hexameric ring about 95 Å in diameter and 45 A ̊ in height, was determined. The centre is filled with a lipid plug that forms an asymmetric bilayer. Amino residues that can be protonated in the periplasmic domain are important for proton sensing or gating.[1]

References

  1. ^ Strugatsky D, McNulty R, Munson K, Chen CK, Soltis SM, Sachs G, Luecke H (January 2013). "Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori". Nature. 493 (7431): 255–8. Bibcode:2013Natur.493..255S. doi:10.1038/nature11684. PMC 3974264. PMID 23222544.



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