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PALM
Identifiers
Aliases	PALM, paralemmin, PALM1
External IDs	OMIM: 608134; MGI: 1261814; HomoloGene: 1937; GeneCards: PALM; OMA:PALM - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	748,329 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,656,730 bp
RNA expression pattern
	Top expressed in
	Amygdala; ; right frontal lobe; ; nucleus accumbens; ; cingulate gyrus; ; anterior cingulate cortex; ; caudate nucleus; ; putamen; ; prefrontal cortex; ; ganglionic eminence; ; Brodmann area 9;
	Top expressed in
	entorhinal cortex; ; perirhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; CA3 field; ; granulocyte; ; ventricular zone; ; neural tube; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	D3 dopamine receptor binding; protein binding;
Cellular component	cytoplasm; cell projection; intracellular membrane-bounded organelle; membrane; filopodium; plasma membrane; dendritic spine; integral component of plasma membrane; dendrite membrane; axon; apicolateral plasma membrane; dendrite; basolateral plasma membrane; dendritic spine membrane; neuron spine; nucleus; filopodium membrane; postsynaptic density; cytoplasmic vesicle; intrinsic component of the cytoplasmic side of the plasma membrane;
Biological process	protein localization; negative regulation of adenylate cyclase activity; cytoskeleton organization; synapse maturation; regulation of cell shape; negative regulation of dopamine receptor signaling pathway; cellular response to electrical stimulus; positive regulation of filopodium assembly; protein localization to plasma membrane; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5064
	18483
	ENSG00000099864
	ENSMUSG00000035863
	O75781
	Q9Z0P4
	NM_001040134; NM_002579
	NM_001161747; NM_023128
	NP_001035224; NP_002570
	NP_001155219; NP_075617
	Wikidata
View/Edit Human	View/Edit Mouse

Paralemmin is a protein that in humans is encoded by the PALM gene.^[5]^[6]^[7]

This gene encodes a member of the paralemmin protein family. Other members of this family include CAP-23, GAP-43, MARCKS, and MacMARCKS. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types.^[5]^[6] Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099864 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035863 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Burwinkel B, Miglierini G, Jenne DE, Gilbert DJ, Copeland NG, Jenkins NA, Ring HZ, Francke U, Kilimann MW (Aug 1998). "Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice". Genomics. 49 (3): 462–6. doi:10.1006/geno.1998.5276. PMID 9615234.
^ ^a ^b Kutzleb C, Sanders G, Yamamoto R, Wang X, Lichte B, Petrasch-Parwez E, Kilimann MW (Dec 1998). "Paralemmin, a Prenyl-Palmitoyl–anchored Phosphoprotein Abundant in Neurons and Implicated in Plasma Membrane Dynamics and Cell Process Formation". J Cell Biol. 143 (3): 795–813. doi:10.1083/jcb.143.3.795. PMC 2148134. PMID 9813098.
^ ^a ^b "Entrez Gene: PALM paralemmin".