Cyclin-dependent kinase inhibitor 1B (p27Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs...

controlling cell cycle regulated translation of the p27Kip1 protein in human cells. The p27kip1 protein is involved in cell cycle regulation and belongs...

cycle. The CIP/KIP family is made up of three proteins: p21cip1/waf1, P27kip1, p57kip2 These proteins share sequence homology at the N-terminal domain...

KAP, Cks1, p27Kip1, and Spy-1 Cdk2 Cyclin E G1 to S phase transition KAP, Cks1, p27Kip1, and Spy-1 Cdk2 Cyclin A S phase KAP, Cks1, p27Kip1, and Spy-1...

proliferation via the phosphorylation of p27Kip1, thus accelerating the degradation rate of p27Kip1. p27Kip1 is a cyclin-dependent kinase (CDK) inhibitor...

Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex"....

all patients. A mechanism of resistance involves failure to downregulate p27Kip1 as well as suppressing p27 translocation to the nucleus in breast cancer...

phosphorylates and destabilises p27Kip1, which results in a low level of p27Kip1. This suggests that the degradation of p27Kip1 is associated with the development...

initiation of DNA duplication. The Cyclin E/CDK2 complex phosphorylates p27Kip1 (an inhibitor of Cyclin D), tagging it for degradation, thus promoting...

H, Fend F, Graw J, Atkinson MJ (October 2006). "Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans". Proc...

proteins that inhibit cell cycle progression at G1, such as p21CipP1, p27Kip1, and p57Kip2. Furthermore, regulators of Cdk4 and Cdk6 activity, such as...

cells. The suspected mechanism is dependent on p27Kip1, a cyclin-dependent kinase inhibitor. p27Kip1 protein levels are elevated in arresting cells....

2002). "The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2". Journal of Immunology. 168 (10): 5024–5031...

Skp2 is an FBP that binds CKIs such as p27Kip1 and p21. Skp2 binds p27Kip1 only when two conditions are met: p27Kip1 is phosphorylated by E/A/CKD2 and bound...

Sivakolundu SG, Bashford D, Kriwacki RW (November 2005). "Disordered p27Kip1 exhibits intrinsic structure resembling the Cdk2/cyclin A-bound conformation"...

particular significance is the role that mTOR plays in the regulation of p27Kip1, an inhibitor of cyclin-dependent kinases such as cdk2. The binding of...

is p27Kip1, which is involved primarily in inhibiting cyclin E-CDK2 complexes (and to a lesser extent cyclin D-CDK4 complexes). Levels of p27Kip1 (like...

in the Cdk-independent pathway involves the recognition of substrates p27Kip1 and p21cip1 by directly associating with E3 SCFSkp2 when stimulated by...

cyclin-dependent kinase inhibitor p27Kip1 rises when FOXO1 is active. A study detects that FOXO1 regulates the nuclear localization of p27Kip1 in porcine granulosa...

2018). "TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer". Oncotarget. 9 (11): 9672–9684. doi:10.18632/oncotarget...

"HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways". Cell Cycle. 4 (1): 87–95. doi:10.4161/cc...

cyclin-dependent kinase (CDK) inhibitors p21Cip1 and p27Kip1, allowing cell cycle progression. Akt phosphorylates p27Kip1 at Thr157, preventing its nuclear import...

Randel E, Gurley KE, Roberts JM, Kemp CJ (November 1998). "The murine gene p27Kip1 is haplo-insufficient for tumour suppression". Nature. 396 (6707): 177–180...

have died and prevent or reverse hearing loss. The cell cycle inhibitor p27Kip1 (CDKN1B) has also been found to encourage regrowth of cochlear hair cells...

Smits AM, Burgering BM (Sep 2008). "The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors". Cancer...

both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2". EMBO Rep. 9 (4): 377–83. doi:10.1038/embor.2008.7. PMC 2288761...

efficiency and binding affinity. Known CDK inhibitors are p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Rosmarinic acid methyl ester is a plant-derived Cdk2 inhibitor...

that OLIG2 can suppress the proliferation of U12-1 by transactivating the p27Kip1 gene and can inhibit the motility of the cell by activating RhoA. Besides...

to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms...

involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of...

Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27Kip1". Cell. 85 (5): 721–732. doi:10.1016/S0092-8674(00)81238-6. PMID 8646780...

of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". J. Biol. Chem. 278 (1): 672–8. doi:10.1074/jbc.M201375200. PMID 12409310...

2002). "PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization" (PDF). Nature...

and NF1. Other reported downstream ALK targets include FOXO3a, CDKN1B(p27Kip1), cyclin D2, NIPA, RAC1, CDC42, BCAR1(p130Cas), SHP1, and PIKFYVE. Phosphorylated...

promotion of cyclin D1 translation, phosphorylation of the Cdk inhibitors p27Kip1 (preventing its nuclear import) and p21Cip1 (decreasing stability), and...

increasing JUNB, JUND, and Fra2, and by decreasing c-JUN through the loss of p27Kip1. JDP2 downregulates p53 transcription, which promotes leukemogenesis. Mouse...

of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". J. Biol. Chem. 278 (1): 672–8. doi:10.1074/jbc.M201375200. PMID 12409310...

protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 Phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer...

Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74...

POU domain, class 4, transcription factor 3". In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult...

transcription (p220/NPAT, CBP/p300, HIRA) and Cdk inhibitors p21Waf1/Cip1 or p27Kip1." The complex interacts with its substrates due to two distinct regions...

"MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1". The Journal of Biological Chemistry. 283 (44): 29897–903. doi:10.1074/jbc...

CDK4/6 with cyclin D (Cánepa et al., 2007). The Cip/Kip families (p21Cip1, p27Kip1, and p57Kip2) also bind to cyclin/CDK complexes and prohibit advancement...

the cell cycle. Other than Rb, viral cyclin D-Cdk6 complex also targets p27Kip1, a Cdk inhibitor of cyclin E and A. In addition, viral cyclin D-Cdk6 is...

Rubin M, Fan Z, DeBlasio T, Soos T, Koff A, Mendelsohn J. Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal...

February 1998). "Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)". Proceedings...

ML, Clurman BE (2002). "Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis"...

of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo". Int J Oncol. 34 (6): 1653–60. doi:10.3892/ijo_00000296...

Bhattacharya N, Slingerland JM (August 2000). "Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer...

Flexibility in Signal Transduction Mediated by the Cell Cycle Regulator, p27Kip1". Journal of Molecular Biology. 376 (3): 827–38. doi:10.1016/j.jmb.2007...

2016). "Nanog induces suppression of senescence through downregulation of p27KIP1 expression". Journal of Cell Science. 129 (5): 912–920. doi:10.1242/jcs...

"Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation". Cell Cycle. 5 (1): 71–7. doi:10.4161/cc.5.1...

cell cycle progression by phosphorylating and inactivating p21Cip1/WAF1, p27Kip1, and GSK3β, as well as inhibits apoptosis by preventing the cleavage of...

expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1". Molecular and Cellular Biology. 25 (11): 4335–48. doi:10.1128/MCB.25...

Yoshida M, Nakayama K, Nakayama KI (April 2002). "Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export". The...

"Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition". The Journal of Biological Chemistry....

"Transforming growth factor-beta, transforming growth factor-beta receptor II, and p27Kip1 expression in nontumorous and neoplastic human pituitaries". The American...

S, Katayama K, Tsuruo T (Aug 2002). "Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization". J. Biol. Chem...

(2017). "TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/P27Kip1 in renal cancer". Oncotarget. 9 (11): 9672–9684. doi:10.18632/oncotarget...

2007). "Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth". Mol. Cell. Biol. 27 (13): 4980–90...

inhibitor MK-886 induces apoptosis in gastric cancer through upregulation of p27kip1 and bax". Journal of Gastroenterology and Hepatology. 19 (1): 31–37. doi:10...

Bhattacharya N, Slingerland JM (August 2000). "Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer...

of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". The Journal of Biological Chemistry. 278 (1): 672–678. doi:10.1074/jbc...

promote proliferation by blocking expression of a cell-cycle inhibitor (p27Kip1). BCL-6 is also an inhibitor of cellular senescence. Cellular senescence...

ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1". Cancer Research. 67 (22): 10789–95. doi:10.1158/0008-5472.CAN-07-2033...

(July 2002). "A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression". The EMBO Journal. 21 (13): 3390–401...

Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1". The Journal of Biological Chemistry. 276 (15): 12084–90. doi:10.1074/jbc...

Kitagawa M (Dec 2006). "Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis". Cancer Research....

protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6): 1199–205. PMID 7882308...

Orthel J, Dill J, Fero ML (March 2007). "Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis"...

the transcription factor FoxM1 and upregulate the cell-cycle inhibitor p27Kip1 (which is regulated by FoxM1-dependent expression of the E3 ubiquitin ligase...

fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression". Proceedings of the National Academy of Sciences of the United...

2004). "Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor...

ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1". Mol. Cell. Biol. 25 (15): 6603–16. doi:10.1128/MCB.25.15.6603-6616.2005...

Patten AK, Massagué J, Pavletich NP (1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex"....

Matli M, Warren RS, Castro AF (Dec 2010). "Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications...

Horst A, et al. (September 2008). "The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors". Cancer...

analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders". Eur. J. Haematol. 74 (5): 424–9...

protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6): 1199–205. PMID 7882308...

cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity"...

(2000). "Characterization and Targeted Disruption of Murine Nup50, a p27Kip1-Interacting Component of the Nuclear Pore Complex". Molecular and Cellular...

"MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1". The Journal of Biological Chemistry. 283 (44): 29897–903. doi:10.1074/jbc...

cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity"...

differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1". Genes & Development. 11 (18): 2335–2346. doi:10.1101/gad.11.18.2335....

and for cell proliferation. MIF4GD has been shown to bind and stabilize p27Kip1, which plays an important role in the regulating the cell cycle and in...

protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Research. 55 (6): 1199–1205...