LCMT2

LCMT2
Identifiers
Aliases	LCMT2, PPM2, TYW4, leucine carboxyl methyltransferase 2
External IDs	OMIM: 611246; MGI: 1353659; GeneCards: LCMT2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	43,330,582 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	120,971,134 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; germinal epithelium; ; gingival epithelium; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; gonad; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; retinal pigment epithelium;
	Top expressed in
	right kidney; ; proximal tubule; ; otic vesicle; ; right ventricle; ; medullary collecting duct; ; medial ganglionic eminence; ; islet of Langerhans; ; epithelium of stomach; ; primitive streak; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; protein binding; S-adenosylmethionine-dependent methyltransferase activity; tRNA methyltransferase activity; protein C-terminal leucine carboxyl O-methyltransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	tRNA modification; methylation; tRNA methylation; wybutosine biosynthetic process; tRNA processing; C-terminal protein methylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9836
	329504
	ENSG00000168806
	ENSMUSG00000074890
	O60294
	Q8BYR1
	NM_014793
	NM_177846
	NP_055608
	NP_808514
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine carboxyl methyltransferase 2 is an enzyme that in humans is encoded by the LCMT2 gene.^[5]^[6]^[7]

The protein encoded by this intronless gene belongs to the methyltransferase superfamily and acts as a G₁/S and G₂/M phase checkpoint regulator. It has been hypothesized that cigarette smoke-induced oxidative stress and transforming growth factor beta 1 may inhibit cellular proliferation by modulating the expression of this protein.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168806 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074890 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
^ Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID 17150819.
^ ^a ^b "Entrez Gene: LCMT2 leucine carboxyl methyltransferase 2".

De Baere I, Derua R, Janssens V, et al. (2000). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry. 38 (50): 16539–47. doi:10.1021/bi991646a. PMID 10600115.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Marwick JA, Kirkham P, Gilmour PS, et al. (2003). "Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells". Ann. N. Y. Acad. Sci. 973: 278–83. doi:10.1111/j.1749-6632.2002.tb04649.x. PMID 12485877. S2CID 84732926.
Ng CC, Arakawa H, Fukuda S, et al. (2003). "p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1". Oncogene. 22 (28): 4449–58. doi:10.1038/sj.onc.1206586. PMID 12853982.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kawamata N, Inagaki N, Mizumura S, et al. (2005). "Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders". Eur. J. Haematol. 74 (5): 424–9. doi:10.1111/j.1600-0609.2005.00417.x. PMID 15813917. S2CID 46197026.
Noma A, Kirino Y, Ikeuchi Y, Suzuki T (2006). "Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA". EMBO J. 25 (10): 2142–54. doi:10.1038/sj.emboj.7601105. PMC 1462984. PMID 16642040.
Liu FY, Qi JP, Xu FL, Wu AP (2006). "Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor". World J. Gastroenterol. 12 (26): 4161–5. doi:10.3748/wjg.v12.i26.4161. PMC 4087364. PMID 16830365.
Moon SK, Choi YH, Kim CH, Choi WS (2006). "p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1". Biochem. Biophys. Res. Commun. 350 (3): 662–8. Bibcode:2006BBRC..350..662M. doi:10.1016/j.bbrc.2006.09.092. PMID 17026958.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168806 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074890 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9628581-5] Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.

[pmid17150819-6] Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID 17150819.

[entrez-7] "Entrez Gene: LCMT2 leucine carboxyl methyltransferase 2".

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LCMT2

References

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