During the Russian Civil War, Novospasivka was the second-most (only behind Huliaipole) important center of the Ukrainian anarchist movement known as the Makhnovshchina. Novospasivka changed hands between the warring factions several times, before eventually falling into control of the Bolsheviks, who established the Soviet Union on much of the former territory of the Russian Empire. The Soviet government incorporated Novospasivka into Berdiansk Okruha of the Ukrainian Soviet Socialist Republic in 1923. In the same year, Novospasivka was designated the center of Novospasivka Raion within the okruha.[1]
In 1925, the raion center was moved to Berdiansk, and it was renamed Berdiansk Raion accordingly. The raion, including Novospasivka, was also transferred to Mariupol Okruha that year. In 1932, the okruha system was scrapped altogether, and Novospasivka became part of Dnipropetrovsk Oblast. As a result of the Holodomor, a manmade famine in the Ukrainian SSR in 1932–1933, over 200 people from Novospasivka are documented to have died.[1]
In 1939, Novospasivka became part of Zaporizhzhia Oblast, a newly created region split off from Dnipropetrovsk Oblast. In the same year, Novospasivka was renamed to Osypenko in honor of Soviet military pilot Polina Osipenko, who was born in the village. During World War II, Osypenko was occupied by Nazi Germany from October 6, 1941 to September 16, 1943.[1]
In 1973, a ceramics factory was founded in Osypenko that produced building materials.[1]
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