Nilotinib, sold under the brand name Tasigna marketed worldwide by Novartis, is a medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome.[4] It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib.[4][5] It is taken by mouth.[5]
Common side effects may include low platelets, low white blood cells, anemia, rashes, vomiting, diarrhea, and joint pains.[5] Other serious side effects may include QT prolongation, sudden death, pancreatitis, and liver problems.[5] It is not safe for use during pregnancy.[5] Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer cell.[5]
Nilotinib was approved for medical use in the United States in 2007.[5] It is on the World Health Organization's List of Essential Medicines.[6] It is approved as a generic medication.[7]
Nilotinib is used to treat Philadelphia chromosome (Ph+)-positive chronic myelogenous leukaemia.[3]
Nilotinib has a number of adverse effects including headache, fatigue, gastrointestinal problems such as nausea, vomiting, diarrhea and constipation, muscle and joint pain, rash and other skin conditions, flu-like symptoms, and reduced blood cell count. Less typical side effects are those of the cardiovascular system, such as high blood pressure, various types of arrhythmia, and prolonged QT interval. Nilotinib can also affect the body's electrolyte and glucose balance.[8] Though lung-related adverse effects are rare when compared with imatinib and dasatinib, there is a case report of acute respiratory failure from diffuse alveolar hemorrhage in a people taking nilotinib.[9]
Nilotinib carries a black box warning in the United States for possible heart complications.[10][2] Contraindications include long QT syndrome, hypokalaemia, hypomagnesaemia, pregnancy, planned pregnancy, lactation and galactose/lactose intolerance.[3][11]
Cautions include:[3]
Dose reduction has been recommended in people with liver problems which involves recommendation of lower starting dose and monitoring of any hepatic function abnormalities.[12]
Hepatitis B virus reactivation may also occur.[13]
Nilotinib has been reported as a substrate for OATP1B1 and OATP1B3. Interaction of nilotinib with OATP1B1 and OATP1B3 may alter its hepatic disposition and can lead to transporter mediated drug-drug interactions.[12] Nilotinib is an inhibitor of OATP-1B1 transporter but not for OATP-1B3.[14]
It is a substrate for CYP3A4 and hence grapefruit juice and other CYP3A4 inhibitors[15] will increase its action and inducers like St. John's wort[16] will decrease it. Patients report that pomegranates and starfruit may also interfere.
Nilotinib inhibits the kinases BCR-ABL,[17] KIT, LCK, EPHA3, EPHA8, DDR1, DDR2, PDGFRB, MAPK11 and ZAK.[18]
Structurally related to imatinib,[19] It is 10–30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells.[19][20][21][22]
Nilotinib was developed by Novartis.[5] It was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance.[23][20][21]
It was approved for medical use by the FDA in October 2007,[8] EMA in September 2009,[24] MHRA in November 2007,[25] and TGA in January 2008.[11]
In June 2024, the Committee for Medicinal Products for Human Use of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Nilotinib Accord, intended for the treatment of chronic myeloid leukemia.[26][27] The applicant for this medicinal product is Accord Healthcare S.L.U.[26] Nilotinib Accord is a generic of Tasigna.[26]
There is weak evidence that nilotinib may be beneficial with Parkinson's disease (PD), with a small clinical trial suggesting it might halt progression and improve symptoms.[28] However, there were significant side effects including infection, liver function tests abnormalities, hallucinations and heart attack, and the benefit in PD disappeared at follow up after drug discontinuation, raising question as to whether it was truly a disease modifying therapy. Nilotinib is currently undergoing phase II studies for treatment of Parkinson's.[29] Scientists and medical professionals have advised caution with over-optimistic interpretation of its effects in Parkinson's due to the significant media hype surrounding the small and early clinical trial.[30][31] Dystonia and cognitive impairment have also been reported as side effects.[32]
Novartis announced in April 2011, that it was discontinuing a phase III trial of nilotinib as the first-line treatment of gastrointestinal stromal tumor (GIST) based on the recommendation of an independent data monitoring committee. Interim results showed Tasigna is unlikely to demonstrate superiority compared to Novartis's Gleevec (imatinib)*, the current standard of care in this setting.[33]
Low dose nilotinib is also being investigated for use in Alzheimer's disease, as well as for ALS, dementia and Huntington's disease.[34]
Mülheim an der Ruhr Ciudad BanderaEscudo Mülheim an der RuhrLocalización de Mülheim an der Ruhr en Alemania Coordenadas 51°25′39″N 6°52′57″E / 51.4275, 6.8825Entidad Ciudad • País Alemania • Estado Renania del Norte-Westfalia • Región DüsseldorfSuperficie • Total 91,26 km² Altitud • Media 26 y 153 m s. n. m.Población (2007) • Total 168 925 hab. • Densidad 1888,74 hab…
Didik SuhardiS.H., M.Si., Ph.D.Deputi Bidang Koordinasi Revolusi Mental, Pemajuan Budaya, dan Peningkatan Prestasi Olahraga Kemenko PMKPetahanaMulai menjabat 14 September 2021Staf Ahli Bidang Transformasi Birokrasi Kementerian Koordinator Bidang Pembangunan Manusia dan Kebudayaan RIMasa jabatan06 Agustus 2020 – 14 September 2021Sekretaris Jenderal Kemdikbud RIMasa jabatan17 Juni 2015[1] – 16 Desember 2019[2]PendahuluProf. Ainun Naim, Ph.D.PenggantiProf. …
Species of bird Golden myna Conservation status Least Concern (IUCN 3.1)[1] Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Aves Order: Passeriformes Family: Sturnidae Genus: Mino Species: M. anais Binomial name Mino anais(Lesson, 1839) The golden myna (Mino anais) is a species of starling in the family Sturnidae. It is found in New Guinea. Its natural habitat is subtropical or tropical moist lowland forest. References ^ BirdLife Internatio…
يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (يوليو 2019) منتخب ترينيداد وتوباغو لكرة القدم الشاطئية معلومات عامة رمز الفيفا TRI الاتحاد اتحاد ترينيداد وتوباغو لك…
Automobile Union Rechtsform Gründung 1899 Auflösung 1899 Sitz Paris, Frankreich Branche Automobilindustrie Esculape von 1899 in der Cité de l’Automobile – Musée National – Collection Schlumpf. Dort mit Baujahr 1898 angegeben. Esculape (französisch für Äskulap) war eine französische Automarke.[1][2][3][4] Inhaltsverzeichnis 1 Unternehmensgeschichte 2 Modelle 3 Literatur 4 Weblinks 5 Einzelnachweise Unternehmensgeschichte Das Unternehmen Automobile Uni…
Ohmi Railway Taga Line220 series electric car at Taga Taisha-mae Station (October 2006)OverviewNative name近江鉄道多賀線TerminiTakamiyaTaga Taisha-maeStations3Websitehttp://www.ohmitetudo.co.jpServiceTypeCommuter railOperator(s)Ohmi RailwayHistoryOpened8 March 1914 (1914-03-08)TechnicalLine length2.5 km (1.6 mi)Track gauge1,067 mm (3 ft 6 in)Electrification1,500 V DC Route map Legend Ohmi Railway Main Line to Maibara 0.0 Takamiya (高宮)…
Pemandangan Ta' Qali dari Mdina Ta' Qali adalah sebuah lapangan terbuka di kawasan Attard di tengah Malta, yang terdiri dari stadion sepak bola nasional, Taman Nasional Ta' Qali, sebuah desa kerajinan, dan sebuah pasar sayuran nasional yang dikenal sebagai Pitkalija. Kedubes AS yang baru dibangun berada di seberang Taman Nasional Ta'Qali.[1] Pada Juli 2011, kedubes tersebut berpindah ke Ta'Qali dari Floriana dimana kedubes tersebut berdiri nyaris lima puluh tahun.[2] Referensi ^ …
Village in Saskatchewan, CanadaZenon ParkVillageZenon ParkShow map of SaskatchewanZenon ParkShow map of CanadaCoordinates: 53°03′50″N 103°45′14″W / 53.064°N 103.754°W / 53.064; -103.754CountryCanadaProvinceSaskatchewanRegionEastern SaskatchewanCensus division14Rural MunicipalityArborfieldPost office Founded1916Incorporated (Village)N/AIncorporated (Town)N/AGovernment • MayorEric Valois • AdministratorLisa LeBlanc • Governing…
This article is about the municipality in Punjab, India. For its namesake district, see Firozpur district. City in Punjab, IndiaFirozpurCityClockwise from top:Saragarhi Memorial in Firozpur, Shaheed Bhagat Singh Stadium, The Barki MemorialFirozpurLocation in Punjab, IndiaShow map of PunjabFirozpurFirozpur (India)Show map of IndiaFirozpurFirozpur (Asia)Show map of AsiaCoordinates: 30°55′00″N 74°36′00″E / 30.9166°N 74.6°E / 30.9166; 74.6Country IndiaStatePu…
У Вікіпедії є статті про інших людей із таким прізвищем: Вірастюк. Роман ВірастюкРоман Ярославович Вірастюк Загальна інформаціяНаціональність українецьГромадянство Україна СРСРНародження 21 квітня 1968(1968-04-21)Івано-ФранківськСмерть 27 липня 2019(2019-07-27)[1] (51 рік)Київ…
Маріян Мрмич Особисті дані Народження 6 травня 1965(1965-05-06) (58 років) Сисак, СФРЮ Зріст 180 см Громадянство Хорватія Позиція воротар Професіональні клуби* Роки Клуб І (г) 1983–1988 «Младост» (Петриня) 111 (-?) 1988–1991 «Динамо» (Вінковці) 58 (-?) 1991–1993 «Цибалія» 48 (-?) 1993–1996 «Вартек…
American politician and attorney (1942–2019) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Frank Ballance – news · newspapers · books · scholar · JSTOR (February 2019) (Learn how and when to remove this template message) Frank BallanceMember of the U.S. House of Representativesfrom North Carolin…
Суперкубок Норвегії з футболу 2018Турнір Суперкубок Норвегії з футболу Ліллестрем Русенборг 0 1 Дата 26 квітня 2018Стадіон Оросен, ЛіллестремАрбітр Том-Гаральд ГагенГлядачі 4 295← 2017 2020 → Суперкубок Норвегії з футболу 2018 — 4-й розіграш турніру. Матч відбувся 26 квітня 2018 р…
Building at Kansas State University This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Nichols Hall – news · newspapers · books · scholar · JSTOR (November 2010) (Learn how and when to remove this template message) Nichols HallNichols Hall, Main EntranceFormer namesNichols CourtGeneral informationTypeAcademic Buil…
Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada Februari 2023. Tari rondang bulan adalah tari tradisional khas Batak Angkola dan Mandailing yang berasal dari Tapanuli Selatan, Sumatera Utara. Penari tarian ini mengenakan pakaian khas suku Batak Angkola dan Mandailing dengan dominasi warna merah, keemasan dan warna h…
El sioux Afraid of Hawk sosteniendo un tomahawk. Tomahawk de principios del siglo XIX. Diferentes estilos de tomahawk. Un tomahawk es un tipo de hacha de guerra originaria de América. Su nombre se incorporó al lenguaje inglés en el siglo XVII como transliteración de la palabra tamahaac proveniente del idioma powhatan (algonquino de Virginia).[1][2] Fue una herramienta empleada tanto por indígenas americanos como por colonos europeos, a menudo también utilizada como …
Wakil Bupati Aceh BaratPetahanaTidak adasejak 11 Oktober 2022Masa jabatan5 tahunDibentuk23 April 2007Pejabat pertamaFuadri, S.Si, M.Si.Situs webacehbaratkab.go.id Berikut ini adalah daftar Wakil Bupati Aceh Barat dari masa ke masa. No Wakil Bupati Mulai Jabatan Akhir Jabatan Prd. Ket. Bupati 1 FuadriS.Si., M.Si. 23 April 2007 23 April 2012 1 H.Ramli M.S. Jabatan kosong 23 April 2012 25 April 2012 - Drs.BukhariM.M.(Pelaksana Harian) 25 April 2012 8 Oktober 2012 Ridwan Ha…
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Kothamangalam SeenuBornV. S. Srinivasan(1910-02-17)17 February 1910Vathirairuppu, Virudhunagar district, Tamil NaduDied30 August 2001(2001-08-30) (aged 91)NationalityIndianOccupation(s)Stage, Film Actor, Carnatic MusicianSpouseAnandavalliChildren5 sons, 4 daughtersParent(s)Subramanya Iyer,Narayani Ammal Kothamangalam Seenu (17 February 1910[1] - 30 August 2001) was a Tamil Stage, Cinema actor and a Carnatic music singer. Early life Kothamangalam Seenu whose birth name is V. S. Srini…
Formula for refraction angles Refraction of light at the interface between two media of different refractive indices, with n2 > n1. Since the velocity is lower in the second medium (v2 < v1), the angle of refraction θ2 is less than the angle of incidence θ1; that is, the ray in the higher-index medium is closer to the normal. Snell's law (also known as the Snell–Descartes law, the ibn-Sahl law, and the law of refraction) is a formula used to describe the relationship between the angles…
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