Neurolysin

Neurolysin
Identifiers
EC no.3.4.24.16
CAS no.149371-24-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Neurolysin (EC 3.4.24.16, neurotensin endopeptidase, endopeptidase 24.16, endo-oligopeptidase B (proline-endopeptidase)) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Preferential cleavage in neurotensin: Pro10-Tyr

This enzyme belongs to the peptidase family M3.

References

  1. ^ Checler F, Vincent JP, Kitabgi P (August 1986). "Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes". The Journal of Biological Chemistry. 261 (24): 11274–81. PMID 3525564.
  2. ^ Barelli H, Vincent JP, Checler F (August 1988). "Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum". European Journal of Biochemistry. 175 (3): 481–9. doi:10.1111/j.1432-1033.1988.tb14220.x. PMID 3409880.
  3. ^ Checler F, Barelli H, Vincent JP (January 1989). "Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies". The Biochemical Journal. 257 (2): 549–54. PMC 1135613. PMID 2649078.