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MMP21
Identifiers
Aliases	MMP21, MMP-21, HTX7, matrix metallopeptidase 21
External IDs	OMIM: 608416; MGI: 2664387; HomoloGene: 17519; GeneCards: MMP21; OMA:MMP21 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	125,775,821 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	133,281,790 bp
RNA expression pattern
	Top expressed in
	gonad; ; corpus epididymis; ; testicle; ; left ovary; ; right ovary; ; body of pancreas; ; minor salivary glands; ; ectocervix; ; right auricle; ; right uterine tube;
	Top expressed in
	embryo; ; blastocyst; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metallopeptidase activity; metal ion binding; zinc ion binding; metalloendopeptidase activity; peptidase activity; hydrolase activity;
Cellular component	extracellular region; extracellular matrix;
Biological process	hematopoietic progenitor cell differentiation; proteolysis; coronary vasculature development; determination of left/right symmetry; determination of heart left/right asymmetry; extracellular matrix organization; collagen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	118856
	214766
	ENSG00000154485
	ENSMUSG00000030981
	Q8N119
	Q8K3F2
	NM_147191
	NM_152944; NM_001320216
	NP_671724
	NP_001307145; NP_694423
	Wikidata
View/Edit Human	View/Edit Mouse

Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene.^[5]^[6]

Function

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154485 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030981 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene. 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011.
^ ^a ^b "Entrez Gene: MMP21 matrix metallopeptidase 21".