My Sex Life... follows the story of a PhD student and lecturer in philosophy, Paul Dédalus, as he struggles to break up with his longtime girlfriend, has conflicted feelings about his two mistresses - who are also his friends' partners -, and has a difficult time facing a new colleague, appointed head of the "epistemology department", a former friend who dislikes him for reasons Paul cannot remember. The Catholic conversion and religious concerns of Paul's younger brother, Ivan, are a subplot in the movie.
Being nearly three hours long, the movie's representation of a daily life in Paris follows a similar pattern to Jean Eustache's The Mother and the Whore from 1973, a cult post-French New Wave film lasting three hours and forty minutes. Similar dialogues and epigrammatic lines or quotations on life, love and friendship are found in both works. Maurice Pialat's interest for "realistic" circumstances has been cited by Desplechin as a major influence on his work in general.[3]
Other versions of the Paul Dédalus character appear in A Christmas Tale (2008) and My Golden Days (2015), the last one being a much more explicit prequel. These later productions both feature Amalric.