Methylated-thiol-coenzyme M methyltransferase

Methylated-thiol-coenzyme M methyltransferase (EC 2.1.1.251, mtsA (gene)) is an enzyme with systematic name methylated-thiol:coenzyme M methyltransferase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction:

methanethiol + coenzyme M ⇌ methyl-CoM + hydrogen sulfide (overall reaction)

(1)

methanethiol + [Co(I) methylated-thiol-specific corrinoid protein] ⇌ [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide

(1a)

[methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M ⇌ methyl-CoM + [Co(I) methylated-thiol-specific corrinoid protein]

(1b)

Methylated-thiol-coenzyme M methyltransferase

Identifiers

Databases

metabolic pathway

PDB structures

RCSB PDB PDBe PDBsum

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This enzyme involved in methanogenesis from methylated thiols, such as methanethiol, dimethyl sulfide, and 3-S-methylmercaptopropionate.

References

^ Paul L, Krzycki JA (November 1996). "Sequence and transcript analysis of a novel Methanosarcina barkeri methyltransferase II homolog and its associated corrinoid protein homologous to methionine synthase". Journal of Bacteriology. 178 (22): 6599–607. doi:10.1128/jb.178.22.6599-6607.1996. PMC 178547. PMID 8932317.
^ Tallant TC, Krzycki JA (November 1997). "Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri, an enzyme of methanogenesis from dimethylsulfide and methylmercaptopropionate". Journal of Bacteriology. 179 (22): 6902–11. doi:10.1128/jb.179.22.6902-6911.1997. PMC 179627. PMID 9371433.
^ Tallant TC, Paul L, Krzycki JA (February 2001). "The MtsA subunit of the methylthiol:coenzyme M methyltransferase of Methanosarcina barkeri catalyses both half-reactions of corrinoid-dependent dimethylsulfide: coenzyme M methyl transfer". The Journal of Biological Chemistry. 276 (6): 4485–93. doi:10.1074/jbc.m007514200. PMID 11073950.

External links

Methylated-thiol---coenzyme+M+methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase
O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase
Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase
Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase Cyclopropane-fatty-acyl-phospholipid synthase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase
Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase
Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase
Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

Arginine:glycine amidinotransferase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)