Inosine monophosphate synthase

ATIC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P4R, 1PKX, 1PL0
Identifiers
Aliases	ATIC, AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
External IDs	OMIM: 601731; MGI: 1351352; HomoloGene: 2983; GeneCards: ATIC; OMA:ATIC - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	215,349,773 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	71,618,790 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; stromal cell of endometrium; ; rectum; ; anterior pituitary; ; ventricular zone; ; right adrenal cortex; ; body of pancreas; ; gonad; ; ganglionic eminence; ; left adrenal cortex;
	Top expressed in
	hand; ; epiblast; ; condyle; ; mandibular prominence; ; maxillary prominence; ; transitional epithelium of urinary bladder; ; abdominal wall; ; mesenteric lymph nodes; ; primitive streak; ; foot;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein homodimerization activity; IMP cyclohydrolase activity; catalytic activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity; hydrolase activity; cadherin binding;
Cellular component	cytosol; membrane; mitochondrion; extracellular exosome; plasma membrane;
Biological process	purine nucleotide biosynthetic process; dihydrofolate metabolic process; 'de novo' IMP biosynthetic process; brainstem development; ribonucleotide metabolic process; cerebellum development; nucleoside metabolic process; tetrahydrofolate biosynthetic process; animal organ regeneration; response to inorganic substance; cerebral cortex development; purine ribonucleoside monophosphate biosynthetic process; metabolism; nucleobase-containing compound metabolic process; cellular response to interleukin-7;
	Sources:Amigo / QuickGO
Orthologs
	471
	108147
	ENSG00000138363
	ENSMUSG00000026192
	P31939
	Q9CWJ9
	NM_004044
	NM_026195
	NP_004035
	NP_080471
	Wikidata
View/Edit Human	View/Edit Mouse

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.^[5]^[6]^[7]

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
EC 3.5.4.10 - IMP cyclohydrolase

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138363 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026192 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping". J Biol Chem. 271 (4): 2225–33. doi:10.1074/jbc.271.4.2225. PMID 8567683.
^ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase". J Biochem. 122 (2): 309–13. doi:10.1093/oxfordjournals.jbchem.a021754. PMID 9378707.
^ "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase".

External links

Inosine+monophosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: P31939 (Human Bifunctional purine biosynthesis protein PURH (Inosine monophosphate synthase)) at the PDBe-KB.