Markada succeeded the village of "Makîsîn" (also spelled "Makasîn", "Maykasan" or "Makîs").[2] During early Islamic rule (7th–10th centuries), Makisin was a town in the district of Diyar Rabi'a with a bridge that crossed the Khabur River.[3] Large quantities of cotton were grown around the site.[3] In the late 680s, numerous Christian Taghlib tribesmen were killed in an ambush at Makisin by the Sulaym tribe as part of the long-running Qays–Yaman feud.[4]
Markada saw fighting between the Syrian Government forces and the al-Nusra Front during 2013.[6][7] Having gained control of the town, the al-Nusra Front were driven out the following year by Islamic State in the Battle of Markada. By March 2014 thousands of residents had fled from Markada, many to al-Sur in Deir ez-Zor Governorate.[8]
US-led Coalition airstrikes against ISIL targeted the town in September 2017, with many casualties, including Iraqi refugees, reported.[9] On 19 October, the SDF attacked the town, capturing part of it.[10][11] The town was fully captured by the SDF on 9 November 2017.