List of progestogens available in the United States
This is a list of progestogens (progesterone and progestins ) and formulations that are approved by the FDA Tooltip Food and Drug Administration in the United States. Progestogens are used as hormonal contraceptives , in hormone replacement therapy for menopausal symptoms , and in the treatment of gynecological disorders .[medical citation needed ]
For contraception
Combined contraceptives
Combined oral contraceptive pills
Drospirenone and Estetrol (Nextstellis)
Estradiol valerate and dienogest (Natazia)
Ethinylestradiol and desogestrel (Bekyree, Cyclessa, Desogen, Emoquette, Enskyce, Isibloom, Kariva, Kimidess, Mircette, Ortho-Cept, Pimtrea, Velivet, Viorele, Volnea)
Ethinylestradiol and drospirenone [and/or levomefolate calcium ] (Beyaz, Loryna, Melamisa, Nikki, Safyral, Syeda, Yaela, Yasmin, Yaz)
Ethinylestradiol and etynodiol diacetate (Demulen 1/35-21, Demulen 1/35-28, Demulen 1/50-21, Demulen 1/50-28, Kelnor, Zovia 1/35E-21, Zovia 1/35E-28, Zovia 1/50E-21, Zovia 1/50E-28)
Ethinylestradiol and levonorgestrel (Alesse, Altavera, Ashlyna, Aviane-21, Aviane-28, Ayuna, Daysee, Elifemme, Enpresse-21, Enpresse-28, Falmina, Fayosim, Introvale, Kurvelo, Lessina-21, Lessina-28, Levlite, Levonest, Levonorgestrel and Ethinyl Estradiol, Levora 0.15/30-21, Levora 0.15/30-28, LoSeasonique, Lybrel, Marlissa, Myzilra, Nordette-21, Nordette-28, Orsythia, Portia-21, Portia-28, Preven Emergency Contraceptive Kit, Quartette, Quasense, Seasonale, Seasonique, Setlakin, Triphasil-21, Triphasil-28, Trivora-21, Trivora-28, Vienva)
Ethinylestradiol and norethisterone [and/or ferrous fumarate (Fe)] (Alyacen 1/35, Alyacen 7/7/7, Alyacen 777, Aranelle, Balziva-21, Balziva-28, Brevicon 21-Day, Brevicon 28-Day, Briellyn, Cyclafem 0.5/35, Cyclafem 1/35, Cyclafem 7/7/7, Dasetta 1/35, Dasetta 7/7/7, Femcon Fe, Gencept 10/11-21, Gencept 10/11-28, Gildagia, Kaitlib Fe, Modicon 21, Modicon 28, N.E.E. 1/35 21, N.E.E. 1/35 28, Norcept-E 1/35 21, Norcept-E 1/35 28, Norethin 1/35E-21, Norethin 1/35E-28, Norinyl 1+35 21-Day, Norinyl 1+35 28-Day, Norquest Fe, Nortrel 0.5/35-21, Nortrel 0.5/35-28, Nortrel 1/35-21, Nortrel 1/35-28, Nortrel 7/7/7, Ortho-Novum 1/35-21, Ortho-Novum 1/35-28, Ortho-Novum 10/11-21, Ortho-Novum 10/11-28, Ortho-Novum 7/14-21, Ortho-Novum 7/14-28, Ortho-Novum 7/7/7-21, Ortho-Novum 7/7/7-28, Ovcon-35, Ovcon-50, Philith, Pirmella 1/35, Pirmella 7/7/7, Tri-Norinyl 21-Day, Tri-Norinyl 28-Day, Vyfemla, Wera)
Ethinylestradiol and norethisterone acetate [and/or ferrous fumarate (Fe)] (Activella, Alyacen 1/35, Alyacen 7/7/7, Alyacen 777, Amabelz, Aranelle, Aurovela 1.5/30,[ 1] Aurovela 1/20,[ 2] Aurovela 24 Fe,[ 3] Aurovela Fe 1.5/30,[ 4] Aurovela Fe 1/20,[ 5] Aurovela Fe,[ 6] Aygestin, Balziva-21, Balziva-28, Blisovi 24 Fe,[ 7] Blisovi Fe 1.5/30,[ 8] Blisovi Fe 1/20,[ 9] Brevicon 21-Day, Brevicon 28-Day, Briellyn, Camila, Chabelina Fe,[ 10] Charlotte 24 Fe,[ 11] Combipatch, Cyclafem 0.5/35, Cyclafem 1/35, Cyclafem 7/7/7, Cyonanz, Dasetta 1/35, Dasetta 7/7/7, Errin, Estrostep 21,[ 12] Estrostep Fe,[ 13] Femcon Fe, Femhrt,[ 14] Finzala,[ 15] Fyavolv,[ 16] Gemmily,[ 17] Gencept 10/11-21, Gencept 10/11-28, Gildagia, Gildess 1.5/30,[ 18] Gildess 1/20,[ 19] Gildess 24 Fe,[ 20] Gildess Fe 1.5/30,[ 21] Gildess Fe 1/20,[ 22] Hailey 1.5/30,[ 23] Hailey 24 Fe,[ 24] Hailey Fe 1.5/30,[ 23] Hailey Fe 1/20,[ 25] Heather, Incassia, Jencycla, Jinteli,[ 26] Junel 1.5/30,[ 27] Junel 1/20, Junel 21,[ 28] Junel Fe 1.5/30,[ 27] Junel Fe 1/20,[ 29] Junel Fe 24,[ 30] Junel Fe 28,[ 28] Kaitlib Fe, Larin 1.5/30,[ 31] Larin 1/20,[ 32] Larin 24 Fe,[ 33] Larin Fe 1.5/30,[ 34] Larin Fe 1/20,[ 35] Leribane, Lo Larin Fe, Lo Loestrin Fe,[ 36] Lo Minastrin Fe, Lo-Blisovi Fe, Loestrin 21 1.5/30, Loestrin 21 1/20, Loestrin 21,[ 37] Loestrin 24 Fe,[ 38] Loestrin Fe 1.5/30, Loestrin Fe 1/20, Loestrin Fe 28,[ 37] Lomedia 24 Fe,[ 39] Lupaneta Pack, Melodetta 24 Fe,[ 40] Merzee,[ 41] Mibelas 24 Fe, Microgestin 1.5/30, Microgestin 1/20, Microgestin Fe 1.5/30, Microgestin Fe 1/20, Micronor, Minastrin 24 Fe, Modicon 21, Modicon 28, Myfembree, N.E.E. 1/35 21, N.E.E. 1/35 28, Nexesta Fe, Nor-Qd, Norcept-E 1/35 21, Norcept-E 1/35 28, Norethin 1/35E-21, Norethin 1/35E-28, Norethin 1/50M-21, Norethin 1/50M-28, Norinyl, Norinyl 1+35 21-Day, Norinyl 1+35 28-Day, Norinyl 1+50 21-Day, Norinyl 1+50 28-Day, Norinyl 1+80 21-Day, Norinyl 1+80 28-Day, Norlestrin 21 1/50, Norlestrin 21 2.5/50, Norlestrin 28 1/50, Norlestrin Fe 1/50, Norlestrin Fe 2.5/50, Norlutate, Norlutin, Norminest Fe, Norquest Fe, Nortrel 0.5/35-21, Nortrel 0.5/35-28, Nortrel 1/35-21, Nortrel 1/35-28, Nortrel 7/7/7, Nylia 1/35, Nylia 7/7/7, Oriahnn (Copackaged), Ortho-Novum 1/35-21, Ortho-Novum 1/35-28, Ortho-Novum 1/50 21, Ortho-Novum 1/50 28, Ortho-Novum 1/80 21, Ortho-Novum 1/80 28, Ortho-Novum 2-21, Ortho-Novum 7/7/7-21, Ortho-Novum 7/7/7-28, Ortho-Novum 7/14-21, Ortho-Novum 7/14-28, Ortho-Novum 10-21, Ortho-Novum 10/11-21, Ortho-Novum 10/11-28, Ovcon-35, Ovcon-50, Philith, Pirmella 1/35, Pirmella 7/7/7, Taytulla, Tri-Legest 21, Tri-Legest 21 , Tri-Legest Fe, Tri-Norinyl 21-Day, Tri-Norinyl 28-Day, Vyfemla, Wera)
Ethinylestradiol and norgestimate (Estarylla, Mili, Mono-Linyah, Ortho Cyclen-21, Ortho Cyclen-28, Ortho Tri-Cyclen, Ortho Tri-Cyclen 21, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Previfem, Sprintec, Tri Lo Sprintec, Tri-Estarylla, Tri-Linyah, Tri-Lo-Estarylla, Tri-Lo-Linyah, Tri-Mili, Tri-Previfem, Tri-Sprintec)
Ethinylestradiol and norgestrel (Cryselle, Elinest, Lo/Ovral, Lo/Ovral-28, Low-Ogestrel-21, Low-Ogestrel-28, Ogestrel 0.5/50-21, Ogestrel 0.5/50-28, Ovral, Ovral-28)
Mestranol and norethisterone (Norinyl 1+50 28-Day)
Transdermal patches
Vaginal rings
Combined injectable contraceptives
Estradiol cypionate and medroxyprogesterone acetate (Lunelle; 5 mg / 25 mg) was previously available in the U.S. but was discontinued.
Progestogen-only contraceptives
Progestogen-only pills
Norgestrel (Ovrette; 0.075 mg) was also previously available in the U.S. as a prescription, but was discontinued in 2005 due to "marketing reasons".[ 44]
Postcoital emergency contraceptive pills
Levonorgestrel (Athentia Next, Fallback Solo, Her Style, Opcicon One-Step, Plan B, Plan B One-Step) – 0.75 mg, 1.5 mg
Progestogen-only injectable contraceptives
Intrauterine devices
Levonorgestrel (Kyleena, Liletta, Mirena, Skyla) – 13.5 mg/device, 19.5 mg/device, 52 mg/device
Progesterone (Progestasert; 38 mg/device) was previously available in the U.S. but was discontinued.
Subcutaneous implants
Etonogestrel (Implanon, Nexplanon) – 68 mg/implant
Levonorgestrel (Jadelle, Norplant, Norplant System in Plastic Container) – 36 mg/implant, 75 mg/implant
For other uses
Combined with estrogen
Oral pills
Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone in oil-filled capsules, is currently pending approval.[ 45]
Estradiol and norgestimate (Prefest; 1 mg / 90 μg) was previously available in the U.S. but was discontinued.
Transdermal patches
Progestogen-only
Oral pills
Medroxyprogesterone acetate (Amen, Curretab, Cycrin, Provera) – 2.5 mg, 5 mg, 10 mg
Megestrol acetate (Megace) – 20 mg, 40 mg – approved specifically for the treatment of breast and endometrial cancer [ 46] and for the treatment of anorexia , cachexia , and weight loss in patients with AIDS Tooltip acquired immunodeficiency syndrome [ 47]
Norethisterone acetate (Aygestin, Norlutate) – 5 mg
Progesterone (Prometrium) – 100 mg, 200 mg, 300 mg
Atypical:
Danazol (Danocrine) – 50 mg, 100 mg, 200 mg – approved specifically for the treatment of endometriosis
Oral suspensions
Vaginal tablets
Vaginal gels
Intramuscular injectables
Miscellaneous
Norethisterone acetate and leuprorelin (Lupaneta Pack) – 5 mg norethisterone acetate oral pills, 3.75 mg/vial, 11.25 mg/vial leuprorelin for intramuscular injection – approved specifically for the treatment of painful endometriosis
Not available in the United States
See also
References
^ "Aurovela 1.5/30- norethindrone acetate and ethinyl estradiol tablet" . DailyMed .
^ "Aurovela 1/20- norethindrone acetate and ethinyl estradiol tablet" . DailyMed .
^ "Aurovela 24 FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Aurovela Fe 1.5/30: FDA-Approved Drugs" . U.S. Food and Drug Administration (FDA) .
^ "Aurovela FE 1/20- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Aurovela FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Blisovi 24 FE- norethindrone acetate and ethinyl estradiol kit" . DailyMed .
^ "Blisovi FE 1.5/30- norethindrone acetate and ethinyl estradiol kit" . DailyMed .
^ "Blisovi FE 1/20- norethindrone acetate and ethinyl estradiol kit" . DailyMed .
^ "Chabelina Fe: FDA-Approved Drugs" . U.S. Food and Drug Administration (FDA) .
^ "Charlotte 24FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Estrostep 21: FDA-Approved Drugs" . U.S. Food and Drug Administration (FDA) .
^ "Estrostep FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Femhrt- norethindrone acetate/ethinyl estradiol tablet" . DailyMed .
^ "Finzala: FDA-Approved Drugs" . U.S. Food and Drug Administration (FDA) .
^ "Fyavolv- norethindrone acetate and ethinyl estradiol tablet, film coated" . DailyMed .
^ "Gemmily- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit" . DailyMed .
^ "Gildess 1.5/30 (norethindrone acetate and ethinyl estradiol tablets, USP)" . DailyMed .
^ "Gildess 1/20 (norethindrone acetate and ethinyl estradiol tablets, USP)" . DailyMed .
^ "Gildess 24 Fe (norethindrone acetate and ethinyl estradiol tablets, USP)" . DailyMed .
^ "Gildess Fe 1.5/30 (norethindrone acetate and ethinyl estradiol tablets, USP)" . DailyMed .
^ "Gildess Fe 1/20 (norethindrone acetate and ethinyl estradiol tablets, USP)" . DailyMed .
^ a b "Hailey FE 1.5/30- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Hailey 24 FE- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit" . DailyMed .
^ "Hailey FE 1/20- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Jinteli- norethindrone acetate and ethinyl estradiol tablet" . DailyMed .
^ a b "Junel FE 1.5/30- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit" . DailyMed .
^ a b "Junel 21 DAY- norethindrone acetate and ethinyl estradiol tablet JUNEL FE 28 DAY- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Junel FE 1/20- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit" . DailyMed .
^ "Junel FE 24- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Larin 1.5/30- norethindrone acetate/ethinyl estradiol kit" . DailyMed .
^ "Larin 1/20- norethindrone acetate/ethinyl estradiol kit" . DailyMed .
^ "Larin 24 FE- norethindrone acetate/ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Larin FE 1.5/30- norethindrone acetate/ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Larin FE 1/20- norethindrone acetate/ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Lo Loestrin FE- norethindrone acetate and ethinyl estradiol, ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ a b "Loestrin 21 DAY- norethindrone acetate and ethinyl estradiol tablet Loestrin FE 28 DAY- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Loestrin 24 FE- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit" . DailyMed .
^ "Lomedia 24 FE- norethindrone acetate and ethinyl estradiol kit" . DailyMed .
^ "Melodetta 24 FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ "Merzee- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit" . DailyMed .
^ Brian Park, PharmD (16 September 2019). "Slynd, a Progestin-Only Contraceptive, Now Available" . Monthly Prescribing Reference (MPR) . Haymarket Media, Inc. Retrieved 5 January 2020 .
^ Commissioner, Office of the (2023-07-13). "FDA Approves First Nonprescription Daily Oral Contraceptive" . FDA . Retrieved 2024-03-17 .
^ Murry, Karen (July 13, 2023). "Decisional Memorandum New Drug Application 17031 Supplement 41 Application for Full Prescription-to-Nonprescription Switch of Norgestrel Tablets 0.075 mg" (PDF) . FDA .
^ Pickar JH, Bon C, Amadio JM, Mirkin S, Bernick B (2015). "Pharmacokinetics of the first combination 17β-estradiol/progesterone capsule in clinical development for menopausal hormone therapy" . Menopause . 22 (12): 1308– 16. doi :10.1097/GME.0000000000000467 . PMC 4666011 . PMID 25944519 .
^ Jame Abraham; James L. Gulley; Carmen J. Allegra (1 September 2009). Bethesda Handbook of Clinical Oncology . Lippincott Williams & Wilkins. pp. 612–. ISBN 978-0-7817-9558-6 .
^ Guido Eibl; Mouad Edderkaoui (22 April 2015). Risk Factors for Pancreatic Cancer: Underlying Mechanisms and Potential Targets . Frontiers Media SA. pp. 96–. ISBN 978-2-88919-468-1 . In 1993, the Food and Drug Administration (FDA) approved megestrol acetate for the treatment of cancer anorexia-cachexia syndrome as well as cachexia due to chronic conditions, including human acquired immunodeficiency syndrome (AIDS).
External links
PR Tooltip Progesterone receptor
Agonists
Testosterone derivatives: Progestins: 6,6-Difluoronorethisterone
6,6-Difluoronorethisterone acetate
17α-Allyl-19-nortestosterone
Allylestrenol
Altrenogest
Chloroethynylnorgestrel
Cingestol
Danazol
Desogestrel
Dienogest
Ethinylandrostenediol
Ethisterone
Ethynerone
Etonogestrel
Etynodiol
Etynodiol diacetate
Gestodene
Gestrinone
Levonorgestrel
Levonorgestrel esters (e.g., levonorgestrel butanoate )
Lynestrenol
Lynestrenol phenylpropionate
Metynodiol
Metynodiol diacetate
Norelgestromin
Norethisterone (norethindrone)
Norethisterone esters (e.g., norethisterone acetate , norethisterone enanthate )
Noretynodrel
Norgesterone
Norgestimate
Norgestrel
Norgestrienone
Norvinisterone
Oxendolone
Quingestanol
Quingestanol acetate
Tibolone
Tigestol
Tosagestin ; Anabolic–androgenic steroids: 11β-Methyl-19-nortestosterone
11β-Methyl-19-nortestosterone dodecylcarbonate
19-Nor-5-androstenediol
19-Nor-5-androstenedione
19-Nordehydroepiandrosterone
Bolandiol
Bolandiol dipropionate
Bolandione
Dimethisterone
Dienedione
Dienolone
Dimethandrolone
Dimethandrolone buciclate
Dimethandrolone dodecylcarbonate
Dimethandrolone undecanoate
Dimethyldienolone
Dimethyltrienolone
Ethyldienolone
Ethylestrenol (ethylnandrol)
Methyldienolone
Metribolone (R-1881)
Methoxydienone (methoxygonadiene)
Mibolerone
Nandrolone
Nandrolone esters (e.g., nandrolone decanoate , nandrolone phenylpropionate )
Norethandrolone
Normethandrone (methylestrenolone, normethandrolone, normethisterone)
RU-2309
Tetrahydrogestrinone
Trenbolone (trienolone)
Trenbolone esters (e.g., trenbolone acetate , trenbolone enanthate )
Trendione
Trestolone
Trestolone acetate
Mixed (SPRMs Tooltip Selective progesterone receptor modulators ) Antagonists
mPR Tooltip Membrane progesterone receptor (PAQR Tooltip Progestin and adipoQ receptor )