Major League Baseball's drug policy prohibits players from using, possessing, selling, facilitating the sale of, distributing, or facilitating the distribution of any Drug of Abuse and/or Steroid. Any and all drugs or substances listed under Schedule II of the Controlled Substances Act are considered drugs of abuse covered by the Program. Players who require prescription medication can still use it with a "Therapeutic Use Exemption" granted by MLB.^[1]

In December 2019, MLB removed cannabinoids and added cocaine and opiates to its list of Drugs of Abuse.^[2] However, players were told that they could still be suspended for possessing or selling cannabis, or driving under the influence of cannabis.^[3]

Sources:^[4][5]

1. Synthetic cannabinoids
2. Cocaine
3. LSD
4. Opiates (e.g., fentanyl, oxycodone, heroin, codeine, and morphine)
5. Amphetamines (e.g., MDMA (Ecstasy), MDA, Meth)
6. "Bath salts" (e.g., cathinone, synthetic cathinone, MDPV)
7. GHB
8. Phencyclidine (PCP)

Prohibited Substances may be added to the list only by the unanimous vote of HPAC, provided that the addition by the federal government of a substance to Schedule I, II, or III will automatically result in that substance being added to the list.^{[citation needed]}