Franklin-Myers was drafted by the Los Angeles Rams in the fourth round (135th overall) of the 2018 NFL draft.[6] The pick used to draft him originally was acquired in a trade that sent Alec Ogletree to the New York Giants.[7] He made his professional debut in the Rams' season opener against the Oakland Raiders. In Week 4, against the Minnesota Vikings, he recorded his first professional sack.[8] As a rookie, he appeared in 16 regular season games. He recorded two sacks, ten total tackles, one forced fumble, and one fumble recovery.[9] He also recorded a sack and a fumble in Super Bowl LIII against New England Patriots quarterback Tom Brady, though the fumble was quickly recovered by the Patriots offense.[10]
Franklin-Myers was waived during final roster cuts on August 31, 2019.[11]
New York Jets
On September 1, 2019, Franklin-Myers was claimed off waivers by the New York Jets.[12] He was placed on injured reserve on October 4, 2019. He was designated for return from injured reserve on November 27, 2019, and began practicing with the team again. However, he was not activated by the end of the three-week practice window on December 18, 2019, and remained on injured reserve for the rest of the season.[13] In the 2020 season, he appeared in 15 games and started two. He finished with three sacks, 19 total tackles (eight solo), two passes defended, and two fumble recoveries.[14]
On October 7, 2021, Franklin-Myers signed a four-year contract extension with the Jets for $55 million, with $30.2 million guaranteed.[15] In the 2021 season, he appeared in and started 16 games. He finished with six sacks, 35 total tackles (17 solo), one interception, one pass defended, and one forced fumble.[16]
In the 2022 season, Franklin-Myers started in all 17 games. He finished with five sacks, 38 total tackles (16 solo), and one pass defended.[17] In the 2023 season, Franklin-Myers started in all 17 games. He finished with 3.5 sacks, 33 total tackles (15 solo), and three passes defended.[18]
Denver Broncos
On April 29, 2024, Franklin-Myers was traded to the Denver Broncos for a 2026 sixth-round pick.[19]