Uwazurike redshirted his true freshman season due to academics.[3] He became a starter during his redshirt freshman season and had 27 tackles, 5.0 tackles for loss, and one sack.[4] In his first full season as a starter, Uwazurike recorded 32 tackles, 5.5 tackles for loss, and 1.5 sacks and was named honorable mention All-Big 12 Conference.[5] He was again named honorable mention All-Big 12 as a redshirt senior after finishing the season with 27 tackles, eight tackles, and three sacks.[6] Uwazurike decided to utilize the extra year of eligibility granted to college athletes who played in the 2020 season due to the coronavirus pandemic and return to Iowa State for a sixth season.[5] He was named first-team in his final season after finishing the year with 43 tackles, 12 tackles for loss, and nine sacks.[7]