The enzyme glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) catalyzes the reaction

6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(α-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(α-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]. Other names in common use include (glycosyl)phosphatidylinositol-specific phospholipase C, GPI-PLC, GPI-specific phospholipase C, VSG-lipase, glycosyl inositol phospholipid anchor-hydrolyzing enzyme, glycosylphosphatidylinositol-phospholipase C, glycosylphosphatidylinositol-specific phospholipase C, variant-surface-glycoprotein phospholipase C, 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol, and diacylglycerol-lyase (1,2-cyclic-phosphate-forming).

• Hereld D, Krakow JL, Bangs JD, Hart GW, Englund PT (1986). "A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein". J. Biol. Chem. 261 (29): 13813–9. doi:10.1016/S0021-9258(18)67092-9. PMID 3759991.
• Carnall N, Webb H, Carrington M (1997). "Mutagenesis study of the glycosylphosphatidylinositol phospholipase C of Trypanosoma brucei". Mol. Biochem. Parasitol. 90 (2): 423–32. doi:10.1016/S0166-6851(97)00177-1. PMID 9476790.
• Armah DA, Mensa-Wilmot K (2000). "Tetramerization of glycosylphosphatidylinositol-specific phospholipase C from Trypanosoma brucei". J. Biol. Chem. 275 (25): 19334–42. doi:10.1074/jbc.M001798200. PMID 10764777.

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