28964
216963
ENSG00000108262
ENSMUSG00000011877
Q9Y2X7
Q68FF6
NM_001085454NM_014030
NM_001004144NM_001374758
NP_001078923NP_054749
NP_001004144NP_001361687
ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene.[5][6][7]
GIT1 contains an ARFGAP domain, Anykrin repeats, and a GRK-interacting domain. The Arf-GAP domain, which enables it to act as a GTPase activating protein (GAP) for the Arf family of GTPases, has been shown to be involved in phosphorylation and inhibition of the ADRB2. If synaptic localization of GIT1 is disturbed, then this is known to affect dendritic spine morphology and formation—this is thought to occur through the Rac1/PAK1/LIMK/CFL1 pathway.[8]
GIT1 has been shown to interact with:
This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.
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