Frenelle-la-Grande (French pronunciation: [fʁənɛl la ɡʁɑ̃d] ⓘ) is a commune in the Vosges department in Grand Est in northeastern France.
Frenelle-la-Grande is adjacent to the department of Meurthe-et-Moselle, at 7 km northwest of Mirecourt. Frenelle-la-Petite is a neighbor to the west.
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