Folate-binding protein

Folate-binding protein (FBP) are proteins that bind folate, typically the folate receptors and reduced folate carrier.[1]

FBP can be a marker for ovarian cancer.[2]

FBP can be measured to help in tumour classification to aid treatment, as it is over-expressed (20-80 fold) in more than 90% of ovarian and endometrial cancers, as well as 20-50% of breast, lung, colorectal, and renal cell carcinomas. FBP has very limited tissue distribution and expression in non-malignant tissue, making it a good immunotherapy target.[3]

Alternative usage

FBP can refer to protein(s) (e.g. extracted from cow's milk) used to do folic acid assays.[4]

References

  1. ^ Kelemen, L. E. (2006). "The role of folate receptor a in cancer development, progression and treatment: Cause, consequence or innocent bystander?". Int. J. Cancer. 119 (2): 243–50. doi:10.1002/ijc.21712. PMID 16453285.
  2. ^ Trowsdale, John; Foulkes, William D.; Jones, Tania A.; Campbell, Ian G. (1991). "Folate-binding Protein Is a Marker for Ovarian Cancer". Cancer Research. 51 (19): 5329–5338. PMID 1717147.
  3. ^ http://www.marketwatch.com/story/galena-biopharma-to-present-at-the-10th-annual-biotechnology-investor-forum-2011-10-21 [dead link‍]
  4. ^ Sobczyńska-Malefora A, Harrington DJ (November 2018). "Laboratory assessment of folate (vitamin B9) status". Journal of Clinical Pathology. 71 (11): 949–956. doi:10.1136/jclinpath-2018-205048. PMID 30228213. S2CID 52297720.


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