Protein-coding gene in the species Homo sapiens
Protocadherin Fat 4 , also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene .[ 5] [ 6]
FAT4 is associated with the Hippo signaling pathway .[ 7]
Clinical significance
Mutations in FAT4 are associated to Hennekam syndrome .[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000196159 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046743 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)" .^ Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol . 337 (2): 307– 17. doi :10.1016/j.jmb.2004.01.026 . PMID 15003449 . ^ Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers" . Int. J. Cancer . 124 (4): 793– 8. doi :10.1002/ijc.23775 . PMC 2667156 PMID 19048595 . ^ Alders, M; Al-Gazali, L; Cordeiro, I; Dallapiccola, B; Garavelli, L; Tuysuz, B; Salehi, F; Haagmans, M. A.; Mook, O. R.; Majoie, C. B.; Mannens, M. M.; Hennekam, R. C. (2014). "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome". Human Genetics . 133 (9): 1161– 1167. doi :10.1007/s00439-014-1456-y . PMID 24913602 . S2CID 14414158 .
Further reading
Katoh Y, Katoh M (2006). "Comparative integromics on FAT1, FAT2, FAT3 and FAT4" . Int. J. Mol. Med . 18 (3): 523– 8. doi :10.3892/ijmm.18.3.523 PMID 16865240 . Caporaso N, Gu F, Chatterjee N, et al. (2009). Reitsma PH (ed.). "Genome-wide and candidate gene association study of cigarette smoking behaviors" . PLOS ONE . 4 (2): e4653. Bibcode :2009PLoSO...4.4653C . doi :10.1371/journal.pone.0004653 PMC 2644817 PMID 19247474 . {{cite journal }}: CS1 maint: article number as page number (link )Liu Y, Blackwood DH, Caesar S, et al. (2010). "Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder" . Molecular Psychiatry . 16 (1): 2– 4. doi :10.1038/mp.2009.107 . PMC 3883627 PMID 20351715 . Need AC, Attix DK, McEvoy JM, et al. (2009). "A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB" . Hum. Mol. Genet . 18 (23): 4650– 61. doi :10.1093/hmg/ddp413 . PMC 2773267 PMID 19734545 . Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score" . Mol. Med . 16 (7– 8): 247– 53. doi :10.2119/molmed.2009.00159 . PMC 2896464 PMID 20379614 . Ballif BA, Villén J, Beausoleil SA, et al. (2004). "Phosphoproteomic analysis of the developing mouse brain" . Mol. Cell. Proteomics . 3 (11): 1093– 101. doi :10.1074/mcp.M400085-MCP200 PMID 15345747 . Johnson AD, Kavousi M, Smith AV, et al. (2009). "Genome-wide association meta-analysis for total serum bilirubin levels" . Hum. Mol. Genet . 18 (14): 2700– 10. doi :10.1093/hmg/ddp202 . PMC 2701336 PMID 19414484 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801– 14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 .
