Protein-coding gene in the species Homo sapiens
Exosome component 4 , also known as EXOSC4 , is a human gene , which is part of the exosome complex .[ 5]
Interactions
Exosome component 4 has been shown to interact with Exosome component 2 .[ 6]
References
Further reading
Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases" . Genes Dev . 13 (16): 2148– 58. doi :10.1101/gad.13.16.2148 . PMC 316947 PMID 10465791 . Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome" . J. Biol. Chem . 276 (9): 6177– 84. doi :10.1074/jbc.M007603200 hdl :2066/186951 PMID 11110791 . Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs" . Cell . 107 (4): 451– 64. doi :10.1016/S0092-8674(01)00578-5 PMID 11719186 . S2CID 14817671 . Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus" . Curr. Biol . 12 (1): 1– 11. Bibcode :2002CBio...12....1A . doi :10.1016/S0960-9822(01)00650-9 PMID 11790298 . S2CID 14132033 . Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol . 315 (4): 809– 18. doi :10.1006/jmbi.2001.5265 . hdl :2066/261980 PMID 11812149 . Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome" . Arthritis Res . 4 (2): 134– 8. doi :10.1186/ar389 PMC 83843 PMID 11879549 . Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol . 323 (4): 653– 63. doi :10.1016/S0022-2836(02)00947-6 . hdl :2066/186665 PMID 12419256 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2003). "The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus" . J. Biol. Chem . 278 (33): 30698– 704. doi :10.1074/jbc.M302488200 hdl :2066/186428 PMID 12788944 . Lejeune F, Li X, Maquat LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities" . Mol. Cell . 12 (3): 675– 87. doi :10.1016/S1097-2765(03)00349-6 PMID 14527413 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation" . Genome Res . 14 (7): 1315– 23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77– 83. Bibcode :2005Natur.433...77A . doi :10.1038/nature03207 . PMID 15635413 . S2CID 4344740 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome . 16 (12): 942– 54. doi :10.1007/s00335-005-0075-2 . PMID 16341674 . S2CID 69278 . van Dijk EL, Schilders G, Pruijn GJ (2007). "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways" . RNA . 13 (7): 1027– 35. doi :10.1261/rna.575107 . PMC 1894934 PMID 17545563 .
PDB gallery
2nn6 : Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40
