Duford was born on June 11, 1898, in Menomonie, Wisconsin.[1] Duford attended Niagara High School[2] and Marquette University, where he played football, baseball, and basketball.[3][4] Duford lettered in basketball from 1921 to 1923.[5] He graduated in 1924.[3]
Duford began his college football coaching career with a two-year stint at the University of Saint Mary in Kansas. He then moved on to Saint Ambrose University in Iowa, where he coached from 1931 to 1939.[6] During his tenure there, Saint Ambrose posted a 60–10–7 record.[3]
Impressed by his winning record, St. Ambrose University signed Duford to a multi-year contract as its football coach. Duford served as both the head football coach and athletic director at Saint Louis from 1940 to 1947.[6] He also served as the basketball coach for the 1944–45 season and posted an 11–6 record.[7] Duford and his staff resigned from Saint Louis after the 1947 season in which the football team amassed a 4–6 record.[8] In his autobiography, Memories of a Hall of Fame Sportswriter, Bob Broeg called Duford his "candidate for the most noble coach of all."[9]
In 1966, Duford was working as the Commissioner of the St. Louis Council on Human Relations,[10] which was set up to facilitate racial integration of the city.[11] Duford returned to Saint Louis University as its interim athletic director in 1967.[6] Duford was inducted into the Saint Louis University's Billiken Hall of Fame in 1995.[12]
Duford died at his Missouri home in 1981 of a heart ailment.[13]