From 1918 to 1921, Anderson played as a guard for the Notre Dame football team, under new head coach Knute Rockne. During his time in South Bend he played under an assumed name for the Canton Bulldogs in 1920–1921, but Anderson later argued that he had only played in exhibition games.[1] From 1922 to 1926, he played professionally for the Cleveland Indians and the Chicago Bears. Anderson played in 39 career games while starting in 32 of them. In 1939, he was an assistant coach for the Detroit Lions under Gus Henderson.
A head coach at Saint Louis for two years, he returned to Notre Dame as an assistant under Rockne in 1930 and the Irish won all ten games. The following spring, Rockne was killed in a plane crash,[2][3][4] and Anderson was promoted to head coach ten days later.[5][6][7]