DSP-4

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DSP-4
Names
Preferred IUPAC name
N-[(2-Bromophenyl)methyl]-2-chloro-N-ethylethan-1-amine
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C11H15BrClN/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12/h3-6H,2,7-9H2, 1H3
    Key: SDJLVPMBBFRBLL-UHFFFAOYSA-N
  • CCN(CCCl)CC1=CC=CC=C1Br
Properties
C11H15BrClN
Molar mass 276.60 g/mol
Density 1.339 g/cm3
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

DSP-4, or N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, is a monoaminergic neurotoxin selective for noradrenergic neurons, capable of crossing the blood–brain barrier.[1]

It exerts transient effects in peripheral sympathetic neurons, but more permanent changes within neurons of the central nervous system. It can induce long-term depletion in cortical and spinal levels of noradrenaline.[2]

See also

References

  1. ^ Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine) Depletes Noradrenaline in Kitten Visual Cortex Without Altering the Effects of Monocular Deprivation". J. Neurosci. 5 (7): 1925–1933. doi:10.1523/jneurosci.05-07-01925.1985. PMC 6565098. PMID 3926960.
  2. ^ Jaim-Etcheverry G, Mari'a Zieher L (1980). "DSP-4: A novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats". Brain Res. 188 (2): 513–523. doi:10.1016/0006-8993(80)90049-9. PMID 7370771. S2CID 36955590.
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