Protein-coding gene in the species Homo sapiens
Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene .[ 5] [ 6] [ 7]
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes . The resting lymphocytes are maintained through suppression of apoptosis , a state which is disrupted by inhibition of this novel serine protease . The enzyme has strong sequence homology with prolyl carboxypeptidase and is active at both acidic and neutral pH.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000176978 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026958 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT (Oct 1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase" . J Immunol . 163 (6): 3092– 9. doi :10.4049/jimmunol.163.6.3092 PMID 10477574 . ^ Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N (Jan 2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II" . Biochem J . 353 (Pt 2): 283– 90. doi :10.1042/0264-6021:3530283 . PMC 1221570 PMID 11139392 . ^ a b "Entrez Gene: DPP7 dipeptidyl-peptidase 7" .
Further reading
Fornas E, Mayordomo F, Renau-Piqueras J, Alborch E (1992). "Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells". Histol. Histopathol . 7 (2): 163– 8. PMID 1515698 . Roberts VJ, Gorenstein C (1990). "The effect of antimitotic agents on the intraneuronal distribution of lysosomes". Brain Res . 521 (1– 2): 62– 72. doi :10.1016/0006-8993(90)91525-L . PMID 2207678 . S2CID 10381435 . Andersen KJ, McDonald JK (1989). "Lysosomal heterogeneity of dipeptidyl peptidase II active on collagen-related peptides". Ren. Physiol. Biochem . 12 (1): 32– 40. doi :10.1159/000173177 . PMID 2727382 . Demuth HU, Schlenzig D, Schierhorn A, Grosche G, Chapotchartier M, Gripon J (1993). "Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases" . FEBS Lett . 320 (1): 23– 7. doi :10.1016/0014-5793(93)81649-K PMID 8096464 . S2CID 24505098 . Underwood R, Chiravuri M, Lee H, Schmitz T, Kabcenell AK, Yardley K, Huber BT (1999). "Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase" . J. Biol. Chem . 274 (48): 34053– 8. doi :10.1074/jbc.274.48.34053 PMID 10567372 . Chiravuri M, Agarraberes F, Mathieu SL, Lee H, Huber BT (2000). "Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase" . J. Immunol . 165 (10): 5695– 702. doi :10.4049/jimmunol.165.10.5695 PMID 11067927 . Araki H, Li Y, Yamamoto Y, Haneda M, Nishi K, Kikkawa R, Ohkubo I (2001). "Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase" . J. Biochem . 129 (2): 279– 88. doi :10.1093/oxfordjournals.jbchem.a002855 PMID 11173530 . Zhan H, Yamamoto Y, Shumiya S, Kunimatsu M, Nishi K, Ohkubo I, Kani K (2002). "Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats". Histochem. J . 33 (9– 10): 511– 21. doi :10.1023/A:1014943522613 . PMID 12005022 . S2CID 29588226 . Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, Thornberry NA (2003). "Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII" . Biochem. J . 371 (Pt 2): 525– 32. doi :10.1042/BJ20021643 . PMC 1223300 PMID 12529175 . Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation" . Genome Res . 14 (7): 1315– 23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 .
