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DGKB
Identifiers
Aliases	DGKB, DAGK2, DGK, DGK-BETA, diacylglycerol kinase beta
External IDs	OMIM: 604070; MGI: 2442474; HomoloGene: 37875; GeneCards: DGKB; OMA:DGKB - orthologs
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	38,684,238 bp
RNA expression pattern
	n/a
	Top expressed in
	dorsal striatum; ; olfactory tubercle; ; mammillary body; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; piriform cortex; ; globus pallidus; ; nucleus accumbens; ; lateral septal nucleus; ; Temporal Lobe;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; calcium ion binding; ATP binding; metal ion binding; kinase activity; diacylglycerol kinase activity; NAD+ kinase activity;
Cellular component	cytoplasm; nucleus; cytosol; plasma membrane; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	platelet activation; protein kinase C-activating G protein-coupled receptor signaling pathway; intracellular signal transduction; phosphorylation; glycerolipid metabolic process; lipid phosphorylation; metabolism; signal transduction; response to bacterium; modulation of chemical synaptic transmission; regulation of postsynapse organization; diacylglycerol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1607
	217480
	ENSG00000136267
	ENSMUSG00000036095
	Q9Y6T7
	Q6NS52
	NM_004080; NM_145695
	NM_178681; NM_001361686; NM_001361688
NP_663733; NP_001337634; NP_001337635; NP_001337636; NP_001337637;
	NP_001337638; NP_001337640; NP_001337641; NP_001337643; NP_001337644; NP_001337645; NP_001337646; NP_001337647; NP_001337648; NP_001337649; NP_001337650; NP_001337651; NP_001337652; NP_001337653
	NP_848796; NP_001348615; NP_001348617
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.^[4]^[5]

Function

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.^[5]