CPLX2

CPLX2
Identifiers
Aliases	CPLX2, 921-L, CPX-2, CPX2, Hfb1, complexin 2
External IDs	OMIM: 605033; MGI: 104726; HomoloGene: 38212; GeneCards: CPLX2; OMA:CPLX2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	175,884,021 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	54,531,730 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; amygdala; ; caudate nucleus; ; anterior cingulate cortex; ; dorsolateral prefrontal cortex; ; prefrontal cortex; ; nucleus accumbens; ; hippocampus proper; ; postcentral gyrus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; olfactory tubercle; ; cerebellar cortex; ; nucleus accumbens; ; globus pallidus; ; subiculum; ; cerebellar vermis; ; lobe of cerebellum; ; piriform cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syntaxin-1 binding; syntaxin binding; SNARE binding; calcium-dependent protein binding;
Cellular component	cytoplasm; cytosol; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; mast cell granule; synapse; synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex; soma; dendrite; SNARE complex; presynapse; calyx of Held; postsynapse; glutamatergic synapse; terminal bouton;
Biological process	cell differentiation; synaptic vesicle exocytosis; nervous system development; positive regulation of synaptic plasticity; vesicle docking involved in exocytosis; regulation of exocytosis; mast cell degranulation; neurotransmitter transport; exocytosis; regulation of synaptic vesicle fusion to presynaptic active zone membrane; regulation of neurotransmitter secretion;
	Sources:Amigo / QuickGO
Orthologs
	10814
	12890
	ENSG00000145920
	ENSMUSG00000025867
	Q6PUV4
	P84086
	NM_001008220; NM_006650; NM_032282
	NM_009946; NM_001362218
	NP_001008221; NP_006641
	NP_034076; NP_001349147
	Wikidata
View/Edit Human	View/Edit Mouse

Complexin-2 is a protein that in humans is encoded by the CPLX2 gene.^[5]^[6]^[7]

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145920 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025867 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McMahon HT, Missler M, Li C, Sudhof TC (Nov 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
^ Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA (Sep 2005). "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity". Gene. 359: 127–37. doi:10.1016/j.gene.2005.07.005. PMID 16162394.
^ ^a ^b "Entrez Gene: CPLX2 complexin 2".