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CHRNB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K58, 2K59, 2KSR, 2LM2
Identifiers
Aliases	CHRNB2, EFNL3, nAChRB2, cholinergic receptor nicotinic beta 2 subunit
External IDs	OMIM: 118507; MGI: 87891; HomoloGene: 595; GeneCards: CHRNB2; OMA:CHRNB2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,580,013 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,671,939 bp
RNA expression pattern
	Top expressed in
	beta cell; ; vena cava; ; lateral nuclear group of thalamus; ; pars reticulata; ; external globus pallidus; ; subthalamic nucleus; ; mucosa of pharynx; ; ventral tegmental area; ; body of tongue; ; pars compacta;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; habenula; ; cerebellar cortex; ; glomerulus; ; dentate gyrus of hippocampal formation granule cell; ; dorsal tegmental nucleus; ; superior colliculus; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine binding; acetylcholine receptor activity; ion channel activity; protein binding; ligand-gated ion channel activity; protein heterodimerization activity; extracellular ligand-gated ion channel activity; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	acetylcholine-gated channel complex; integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; cell junction; external side of plasma membrane; integral component of plasma membrane; neuron projection; plasma membrane raft; dopaminergic synapse; cholinergic synapse; integral component of presynaptic membrane; integral component of postsynaptic specialization membrane;
Biological process	visual learning; regulation of synaptic transmission, dopaminergic; response to cocaine; smooth muscle contraction; regulation of circadian sleep/wake cycle, REM sleep; regulation of dopamine secretion; response to hypoxia; associative learning; cognition; locomotory behavior; protein heterooligomerization; central nervous system neuron axonogenesis; optic nerve morphogenesis; regulation of synapse assembly; regulation of membrane potential; response to nicotine; membrane depolarization; nervous system process; synaptic transmission, cholinergic; ion transport; hearing; learning; memory; negative regulation of action potential; regulation of dopamine metabolic process; behavioral response to nicotine; regulation of dendrite morphogenesis; B cell activation; neuromuscular synaptic transmission; synaptic transmission involved in micturition; positive regulation of dopamine secretion; positive regulation of B cell proliferation; regulation of circadian sleep/wake cycle, non-REM sleep; vestibulocochlear nerve development; conditioned taste aversion; transport; social behavior; action potential; sensory perception of pain; lateral geniculate nucleus development; positive regulation of synaptic transmission, dopaminergic; response to ethanol; central nervous system projection neuron axonogenesis; calcium ion transport; signal transduction; visual perception; ion transmembrane transport; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; acetylcholine receptor signaling pathway; chemical synaptic transmission; response to acetylcholine; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1141
	11444
	ENSG00000160716
	ENSMUSG00000027950
	P17787
	Q9ERK7
	NM_000748
	NM_009602
	NP_000739
	NP_033732
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene.^[5]^[6]

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.^[6]

It has been discovered that suppression, rather than stimulation, of B2-containing nAChR currents yields an antidepressant effect. This is believed to explain the significantly increased prevalence of cigarette smoking in depressed individuals and the profound rise in depressive symptoms during abstinence.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160716 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027950 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
^ ^a ^b "Entrez Gene: CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)".

External links

CHRNB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CHRNB2 genome location and CHRNB2 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P17787 (Neuronal acetylcholine receptor subunit beta-2) at the PDBe-KB.