CHMP5

CHMP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LXM, 3ULY, 3UM0, 3UM1, 3UM2, 4TXR
Identifiers
Aliases	CHMP5, C9orf83, HSPC177, PNAS-2, SNF7DC2, Vps60, CGI-34, charged multivesicular body protein 5
External IDs	OMIM: 610900; MGI: 1924209; HomoloGene: 5757; GeneCards: CHMP5; OMA:CHMP5 - orthologs
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	40,965,303 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; palpebral conjunctiva; ; amniotic fluid; ; visceral pleura; ; sperm; ; parietal pleura; ; bronchial epithelial cell; ; endothelial cell; ; jejunal mucosa; ; glomerulus;
	Top expressed in
	transitional epithelium of urinary bladder; ; right lung lobe; ; vestibular membrane of cochlear duct; ; pineal gland; ; superior cervical ganglion; ; facial motor nucleus; ; medial ganglionic eminence; ; conjunctival fornix; ; anterior horn of spinal cord; ; gastric mucosa;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; cadherin binding;
Cellular component	cytoplasm; cytosol; endosome; membrane; endosome membrane; extracellular exosome; nucleus;
Biological process	regulation of centrosome duplication; viral life cycle; nucleus organization; multivesicular body sorting pathway; endosome to lysosome transport; multivesicular body assembly; regulation of mitotic spindle assembly; endosomal transport; protein transport; septum digestion after cytokinesis; mitotic metaphase plate congression; regulation of receptor recycling; lysosome organization; vacuolar transport; ESCRT III complex disassembly; transport; midbody abscission; cellular response to lipopolysaccharide; cellular response to muramyl dipeptide;
	Sources:Amigo / QuickGO
Orthologs
	51510
	76959
	n/a
	ENSMUSG00000028419
	Q9NZZ3
	Q9D7S9
	NM_016410; NM_001195536
	NM_029814
	NP_001182465; NP_057494
	NP_084090
	Wikidata
View/Edit Human	View/Edit Mouse

Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.^[4]^[5]^[6]

Function

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.^[6]^[7]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028419 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J (Mar 2005). "The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells". J Biol Chem. 280 (11): 10548–55. doi:10.1074/jbc.M413734200. PMID 15644320.
^ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.
^ ^a ^b "Entrez Gene: CHMP5 chromatin modifying protein 5".
^ Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (September 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.