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BABAM2
Identifiers
Aliases	BABAM2, BRCC4, BRCC45, BRE, brain and reproductive organ-expressed (TNFRSF1A modulator), BRISC and BRCA1 A complex member 2
External IDs	OMIM: 610497; MGI: 1333875; HomoloGene: 3604; GeneCards: BABAM2; OMA:BABAM2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	28,338,901 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	32,242,306 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; gastrocnemius muscle; ; right auricle; ; popliteal artery; ; tibial arteries; ; left ventricle; ; muscle of thigh; ; anterior pituitary;
	Top expressed in
	lens; ; transitional epithelium of urinary bladder; ; adrenal gland; ; ankle; ; brown adipose tissue; ; granulocyte; ; epithelium of lens; ; left lobe of liver; ; muscle of thigh; ; epithelium of stomach;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peroxisome targeting sequence binding; polyubiquitin modification-dependent protein binding; protein binding; tumor necrosis factor receptor binding;
Cellular component	nuclear ubiquitin ligase complex; nucleoplasm; nucleus; cytoplasm; cytosol; BRCA1-A complex; BRISC complex;
Biological process	response to ionizing radiation; positive regulation of DNA repair; cell division; protein K63-linked deubiquitination; cell cycle; double-strand break repair via nonhomologous end joining; signal transduction; apoptotic process; DNA repair; cellular response to DNA damage stimulus; double-strand break repair; protein deubiquitination; negative regulation of apoptotic process; mitotic G2 DNA damage checkpoint signaling; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	9577
	107976
	ENSG00000158019
	ENSMUSG00000052139
	Q9NXR7
	Q8K3W0
NM_001261840; NM_001329112; NM_001329113; NM_001329114; NM_001329115;
	NM_004899; NM_199191; NM_199192; NM_199193; NM_199194
	NM_144541; NM_181279; NM_181280; NM_181281; NM_181282
NP_001248769; NP_001316041; NP_001316042; NP_001316043; NP_001316044;
	NP_004890; NP_954661; NP_954662; NP_954663; NP_954664
	NP_653124; NP_851796; NP_851797; NP_851798; NP_851799
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.^[5]^[6]^[7]

Repair of DNA damage

BRE, the protein product of the BRE (gene), is a core component of the deubiquitin complex BRCA1-A.^[8] Other core components of the BRCA1-A complex are the BRCC36 protein (BRCC3 gene), MERIT40 protein (BABAM1 gene), and RAP80 protein (UIMC1 gene).^[8]

BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks. Sequestration of BRCA1 away from the DNA damage site suppresses homologous recombination and redirects the cell in the direction of repair by the process of non-homologous end joining (NHEJ).^[8] The role of BRCA1-A appears to be to bind BRCA1 with high affinity and withdraw it away from the site of DNA damage to the periphery where it remains sequestered, thus promoting NHEJ in preference to HR.