BP-897

BP-897
Clinical data
ATC code
  • none
Identifiers
  • N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.150.041 Edit this at Wikidata
Chemical and physical data
FormulaC26H31N3O2
Molar mass417.553 g·mol−1
3D model (JSmol)
  • COc1ccccc1N3CCN(CC3)CCCCNC(=O)c4ccc2ccccc2c4
  • InChI=1S/C26H31N3O2/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30) ☒N
  • Key:MNHDKMDLOJSCGN-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

BP-897 is a drug used in scientific research which acts as a potent selective dopamine D3 receptor partial agonist with an in vitro intrinsic activity of ~0.6 and ~70x greater affinity for D3 over D2 receptors and is suspected to have partial agonist or antagonist activity in vivo.[1] It has mainly been used in the study of treatments for cocaine addiction.[2][3][4][5][6][7][8] A study comparing BP-897 with the potent, antagonistic, and highly D3 selective SB-277,011-A found, "SB 277011-A (1–10 mg/kg) was able to block cue-induced reinstatement of nicotine-seeking, indicating that DRD3 selective antagonism may be an effective approach to prevent relapse for nicotine. In contrast, BP 897 did not block the cue-induced reinstatement of nicotine-seeking or nicotine-taking under the FR5 schedule."[9]

References

  1. ^ Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, et al. (July 1999). "Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist". Nature. 400 (6742): 371–375. doi:10.1038/22560. PMID 10432116. S2CID 4351316.
  2. ^ Beardsley PM, Sokoloff P, Balster RL, Schwartz JC (February 2001). "The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered". Behavioural Pharmacology. 12 (1): 1–11. doi:10.1097/00008877-200102000-00001. PMID 11270507. S2CID 25443354.
  3. ^ Garcia-Ladona FJ, Cox BF (2003). "BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction". CNS Drug Reviews. 9 (2): 141–158. doi:10.1111/j.1527-3458.2003.tb00246.x. PMC 6741652. PMID 12847556.
  4. ^ Duarte C, Lefebvre C, Chaperon F, Hamon M, Thiébot MH (November 2003). "Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats". Neuropsychopharmacology. 28 (11): 1903–1915. doi:10.1038/sj.npp.1300276. PMID 12915863.
  5. ^ Hsu A, Togasaki DM, Bezard E, Sokoloff P, Langston JW, Di Monte DA, Quik M (November 2004). "Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys". The Journal of Pharmacology and Experimental Therapeutics. 311 (2): 770–777. doi:10.1124/jpet.104.071142. PMID 15226382. S2CID 15481124.
  6. ^ Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, et al. (July 2005). "Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors". Synapse. 57 (1): 17–28. doi:10.1002/syn.20152. PMC 3726034. PMID 15858839.
  7. ^ Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR, Heidbreder C, et al. (March 2008). "The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats". Psychopharmacology. 196 (4): 533–542. doi:10.1007/s00213-007-0986-6. PMC 3713235. PMID 17985117.
  8. ^ Hocke C, Prante O, Salama I, Hübner H, Löber S, Kuwert T, Gmeiner P (May 2008). "18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor". ChemMedChem. 3 (5): 788–793. doi:10.1002/cmdc.200700327. PMID 18306190. S2CID 23143152.
  9. ^ Khaled MA, Farid Araki K, Li B, Coen KM, Marinelli PW, Varga J, et al. (March 2010). "The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking". The International Journal of Neuropsychopharmacology. 13 (2): 181–190. doi:10.1017/S1461145709991064. PMID 19995481.
Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

Read other articles:

Denganmu (album Cas)

DenganmuAlbum studio karya CasDirilis16 Juli 2009GenreR&BLabelNyos RecordKronologi Cas -String Module Error: Match not foundString Module Error: Match not found Denganmu (2009) Yang Terbaik (2010)String Module Error: Match not foundString Module Error: Match not found Denganmu merupakan sebuah album musik perdana milik penyanyi R&B Indonesia, Cas. Album ini dirilis pada tahun 2009.[1] Daftar lagu No.JudulLirikDurasi1.Apa Yang Kau MauCassanova Alfonso NainggolanWisnu Prasto...

 

 

Ishockey

Uppslagsordet ”Hockey” leder hit. För andra betydelser, se Hockey (varianter). Ishockey En match mellan Atlanta Thrashers och Florida Panthers i National Hockey League (NHL) 2005.Högsta förbundIIHFSmeknamnHockeyFörst utövadVictoria Skating Rink, Montréal (Québec, Kanada), den 3 mars 1875; första organiserade inomhusspelet.Registrerade spelare1 807 937 (2015)[1]KlubbarJaEgenskaperKontaktsportKollisionLagmedlemmarFem utespelare och en målvaktKönsmixadJa, separata tävlin...

 

 

Mii-dera

Halaman ini berisi artikel tentang kuil di Prefektur Shiga. Untuk kuil di Prefektur Nara, lihat Mii-dera (Nara). Mii-dera三井寺 Mii-dera no Bansho (三井寺の晩鐘), lonceng sore hari di Mii-dera. Informasi Denominasi Tendai Jimon Didirikan 672 Pendiri Kaisar Temmu Alamat 246 Onjō-ji-chō, Ōtsu, Shiga Negara Jepang Situs [www.shiga-miidera.or.jp/ homepage] Portal:Agama Buddha Balai Emas (Harta Karun Nasional Jepang) Video Mii-dera (三井寺,御井寺code: ja is deprecated ), yang awa...

Willie Warde

English actor-dancer Warde in 1911 Willie Warde (1857 – 18 August 1943) was an English actor, dancer, singer and choreographer. The son of a dancer, his first theatre work was with a dance company. He was engaged to arrange dances for London productions and was later cast as a comic actor in musical theatre. He was associated for over two decades with the Gaiety and Daly's theatres under the management of George Edwardes, playing in and choreographing burlesques and, later, Edwardian musica...

 

 

Neel Dutt

Indian composer This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libelous.Find sources: Neel Dutt – news · newspapers · books · scholar · JSTOR (August 2019) (Learn how and when to remove this template message) Neel Du...

 

 

Carl Larsson

Carl LarssonSelf-portrait (1895)Lahir(1853-05-28)28 Mei 1853[1]Stockholm, SwediaMeninggal22 Januari 1919(1919-01-22) (umur 65)Falun, SwediaKebangsaanSwediaPendidikanRoyal Swedish Academy of Arts, StockholmDikenal atasPelukisPenulis Tanda tangan Carl Olof Larsson (28 Mei 1853 – 22 Januari 1919) adalah seorang pelukis Swedia yang mewakili gerakan Seni dan Kerajinan. Banyak lukisannya termasuk minyak, cat air, dan lukisan dinding. Dia terutama dikenal karena cat air...

Cape Cod

Cape in the northeastern United States This article is about the area of Massachusetts. For other uses, see Cape Cod (disambiguation). Cape CodCapeCape Cod National SeashoreCape Cod (Barnstable County), in MassachusettsCoordinates: 41°41′N 70°12′W / 41.68°N 70.2°W / 41.68; -70.2LocationMassachusetts, United StatesOffshore water bodiesCape Cod BayBuzzards BayCape Cod CanalNantucket SoundArea • Total339 sq mi (880 km2)[1]Elevati...

 

 

1758 en santé et médecine

Chronologies Données clés 1755 1756 1757  1758  1759 1760 1761Décennies :1720 1730 1740  1750  1760 1770 1780Siècles :XVIe XVIIe  XVIIIe  XIXe XXeMillénaires :-Ier Ier  IIe  IIIe Chronologies thématiques Art Architecture, Arts plastiques (Dessin, Gravure, Peinture et Sculpture), (), Littérature (), Musique (Classique) et Théâtre   Ingénierie (), Architecture et ()   Politique Droit   Religion (,)   Science (...

 

 

James Russell Lowell

Questa voce sull'argomento scrittori statunitensi è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. James Russell Lowell nel 1855 circaFirma di James Russell LowellJames Russell Lowell (Cambridge, 22 febbraio 1819 – Cambridge, 12 agosto 1891) è stato un poeta, critico letterario e diplomatico statunitense, incluso nella lista di personaggi della Hall of Fame for Great Americans. Indice 1 Biografia 2 C...

ソー (オー＝ド＝セーヌ県)

Sceaux 行政国 フランス地域圏 (Région) イル＝ド＝フランス地域圏県 (département) オー＝ド＝セーヌ県郡 (arrondissement) アントニー郡小郡 (canton) 小郡庁所在地INSEEコード 92071郵便番号 92330市長（任期） フィリップ・ローラン（2008年-2014年）自治体間連合 (fr) メトロポール・デュ・グラン・パリ人口動態人口 19,679人（2007年）人口密度 5466人/km2住民の呼称 Scéens地理座標 北緯48度4...

 

 

History of the Constitution of the Roman Republic

Politics of ancient Rome Periods Roman Kingdom753–509 BC Roman Republic509–27 BC Roman Empire27 BC – AD 395 Principate27 BC – AD 284 DominateAD 284–641 WesternAD 395–476 EasternAD 395–1453 Timeline Constitution Kingdom Republic Sullan republic Empire Augustan reforms Late Empire Political institutions Imperium Collegiality Auctoritas Roman citizenship Cursus honorum Assemblies Centuriate Curiate Plebeian Tribal Ordinary magistrates Consul Praetor Quaestor Promagistrate Aedile T...

 

 

Wahai, Seram Utara, Maluku Tengah

WahaiNegeriNegara IndonesiaProvinsiMalukuKabupatenMaluku TengahKecamatanSeram Utara Wahai adalah sebuah negeri yang berada di Kecamatan Seram Utara, Kabupaten Maluku Tengah, Provinsi Maluku. Ibu kota kecamatan Seram Utara terletak di negeri Wahai. Transportasi Bandar Udara Wahai terletak di desa ini. Bandar udara ini memiliki panjang landasan pacu 750 M dan lebar 23 M. Landasan pacu tersebut dapat menampung maksimal 2 pesawat DHC-6 Twin Otter, serta terdapat gedung terminal penumpang den...

Llofriu

You can help expand this article with text translated from the corresponding article in Catalan. (May 2023) Click [show] for important translation instructions. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia. Do not translate text that appears unreliable or low-qu...

 

 

David Headley

This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) references (Learn how and when to remove this message) Convicted American terrorist, co-plotter of the 2008 Mumbai attacks David HeadleyBornDaood Sayed Gilani (1960-06-30) June 30, 1960 (age 63)Washington, D.C., U.S.Occupation(s)Video store proprietorDEA informantChildren4[1]Parent(s)Sayed Salim Gilani (father)Alice Serrill Head...

 

 

Kau & Dia 2

Kau & Dia 2Poster resmiSutradaraIvan BandhitoProduser Agung Priyanto Dwi Nugroho Risti Nanda Dhea Putri SkenarioFiona MahdalenaCeritaBruno GohPemeran Anneth Delliecia Ari Irham Gabriel Prince Zara Leola Bima Azriel Azela Putri SinematograferDoanmario HutajuluPerusahaanproduksi Trinity Optima Production BC Entertainment DistributorMAXStreamTanggal rilis 1 Juli 2022 (2022-07-01) Durasi117 menitNegaraIndonesiaBahasaIndonesia Kau & Dia 2 adalah film drama romantis Indonesia tahun 202...

Internet

Disambiguazione – Se stai cercando il tipo di rete di computer, vedi Internet (informatica). Icona usata per raffigurare Internet nel progetto Tango. Con il termine Internet[1][2][3][4] si intende l'insieme di tutti i dispositivi collegati in rete mediante i protocolli TCP/IP, con i sistemi fisici di comunicazione che li collegano, gli apparati necessari per la loro interconnessione atti a formare reti di computer e le tecnologie che permettono a tali reti d...

 

 

Arkema

ArkemaJenisSociété AnonymeKode emitenEuronext: AKEKomponen CAC Next 20IndustriIndustri kimiaDidirikan2004; 20 tahun lalu (2004)KantorpusatColombes, PrancisWilayah operasiSeluruh duniaTokohkunciThierry Le Hénaff (CEO)Pendapatan€7,9 milyarKaryawan20.500Situs webwww.arkema.com Arkema adalah kelompok bahan kimia Prancis, lebih khusus lagi dalam bahan kimia khusus dan bahan kinerja. Kantor pusatnya berlokasi di Colombes, di Hauts-de-Seine di Prancis.[1] Grup ini mempekerjaka...

 

 

Jefferson Starship

American rock band Not to be confused with Jefferson Airplane or Starship (band). This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Jefferson Starship – news · newspapers · books · scholar · JSTOR (September 2022) (Learn how and when to remove this message) Jefferson StarshipJefferson Starship in 1976 (left to...

العلاقات السلوفاكية الفنزويلية

العلاقات السلوفاكية الفنزويلية سلوفاكيا فنزويلا   سلوفاكيا   فنزويلا تعديل مصدري - تعديل   العلاقات السلوفاكية الفنزويلية هي العلاقات الثنائية التي تجمع بين سلوفاكيا وفنزويلا.[1][2][3][4][5] مقارنة بين البلدين هذه مقارنة عامة ومرجعية للدولتي�...

 

 

Edward Jenner

English physician and pioneer of vaccines (1749–1823) For the New Zealand poet and translator, see Edward Jenner (writer). Edward JennerFRS FRCPEBorn17 May 1749 (1749-05-17)Berkeley, Gloucestershire, EnglandDied26 January 1823(1823-01-26) (aged 73)Berkeley, Gloucestershire, EnglandAlma mater St George's, University of London University of St Andrews Known forVaccinationSmallpox vaccineSpouse Catherine Kingscope ​ ​(m. 1788; died ...