Amidorphin is an endogenous, C-terminally amidated, opioid peptide generated as a cleavage product of proenkephalin A in some mammalian species; in humans and most other species, the peptide is 1 residue longer and is not amidated. Amidorphin is widely distributed in the mammalian brain, with particularly high concentrations found in the striatum, and outside of the brain in adrenal medulla and posterior pituitary.[1][2] The 26-residue peptide named amidorphin is found in several species including bovine (Bos taurus), sheep (Ovis aries), and pig (Sus scrofa). Humans and commonly studied lab animals (mice, rats) produce a 27-residue peptide that does not have an amidated C-terminal residue; this is due to the absence of a Gly in the precursor sequence and replacement with Ala, which is not a substrate for the amidating enzyme (Peptidyl-glycine alpha-amidating monooxygenase). The properties of the 27-residue peptide are presumably similar to those of amidorphin, although this has not been adequately tested.
In some brain areas, amidorphin is extensively further reduced into smaller fragments, such as the non-opioid peptide amidorphin-(8-26), or in humans, amidorphin-8-27. Cleavage of amidorphin into these smaller fragments releases the N-terminal [Met]-enkephalin sequence of amidorphin.[3]
Двузначные почтовые зоны Грузии (определяются по первым двум цифрам почтового индекса) Почтовые индексы Грузии представляют собой систему четырёхзначных цифровых кодов, находящихся в почтовом употреблении на территории Грузии. Содержание 1 История 2 Описание 3 Абхазия и …
Department of Education in Gauteng Gauteng Department of EducationDepartment overviewFormed1994Preceding DepartmentTransvaal Education DepartmentJurisdictionGovernment of GautengHeadquarters17 Simmonds Street, Marshalltown, Johannesburg, 2000Annual budgetR63.4 billion (2023)Member of the Executive Council responsibleMatome ChiloaneDepartment executiveRufus Mmutlana (Acting), Head of DepartmentWebsiteeducation.gauteng.gov.za The Gauteng Department of Education is a provincial government departmen…
Sherina MunafSherina pada tahun 2023LahirSinna Sherina Munaf11 Juni 1990 (umur 33)Bandung, Jawa Barat, IndonesiaKebangsaanIndonesiaAlmamater British School Jakarta University of Sydney PekerjaanPenyanyi-penulis lagukomposerpemeranmodelTahun aktif1999–sekarangSuami/istriBaskara Mahendra (m. 2020)Orang tuaTriawan Munaf (ayah)KerabatFariz Rustam Munaf (paman)Karier musikGenrePopR&BInstrumenVokalPianoLabel Ceepee Production (1999–2002) Trinity Optima …
Gereja Lospalos Peta Lospalos Lospalos (kadang-kadang keliru ditulis Los Palos) adalah kota di Timor Leste. Letaknya 248 km di timur Dili, ibu kota negara itu. Lospalos dihuni oleh 28.000 penduduk dan merupakan ibu kota dari distrik Lautém. Lospalos adalah kota kelahiran pemimpin gerilya kemerdekaan Timor Leste, Nino Konis Santana (1959-1998). Di dunia internasional, kota ini sering kali keliru disebut Los Palos, sehingga kesannya nama ini berasal dari bahasa Spanyol. Kenyataannya, nama in…
هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (أبريل 2019) مارشال درو معلومات شخصية الميلاد 11 يناير 1984 (39 سنة) كلاركسديل مواطنة الولايات المتحدة الحياة العملية المهنة مغن مؤلف، ومغني تعديل مصدري - تعدي
Muzakkar A. GaniBupati Bireuen ke-6Masa jabatan18 Juni 2020 – 10 Agustus 2022Penjabat: 19 Januari 2020—18 Juni 2020PresidenJoko WidodoGubernurNova Iriansyah (Plt.)PendahuluSaifannurWakil Bupati Bireuen ke-4Masa jabatan22 Mei 2017 – 19 Januari 2020PendahuluMukhtar Informasi pribadiLahir7 Desember 1959 (umur 63)Meunasah Krueng Dhoe, Kembang Tanjong, Pidie, AcehKebangsaanIndonesiaPartai politik DemokratSuami/istriHj. Nurjannah AliAlma materUniversitas…
Horse race Mermaid StakesGrade 3 raceGullveig wins the 2012 Mermaid StakesLocationHanshin RacecourseInaugurated1990Race typeThoroughbred Flat racingRace informationDistance2000 metresSurfaceTurfTrackRight-handedQualification3-y-o+ fillies and maresWeightHandicapPurse¥77,360,000 (total), ¥36,000,000 (winner) The Mermaid Stakes (Japanese マーメイドステークス) is a Grade 3 horse race for Thoroughbred fillies and mares aged three and over, run in June over a distance of 2000 metres on tu…
1928 film Don't MarryLobby cardDirected byJames TinlingWritten byRandall Faye William KernellStory byPhilip Klein Sidney LanfieldStarringLois Moran Neil Hamilton Henry KolkerCinematographyJoseph H. AugustProductioncompanyFox FilmDistributed byFox FilmRelease date June 13, 1928 (1928-06-13) Running time60 minutesCountryUnited StatesLanguageSilent (English intertitles) Don't Marry is a 1928 American silent comedy film directed by James Tinling and starring Lois Moran, Neil Hamilton,…
Ruling political coalition of Malaysia Sabah People's Coalition Gabungan Rakyat SabahMalay nameGabungan Rakyat Sabahݢابوڠن رعيت سابهChinese name沙巴人民聯盟沙巴人民联盟Sa-pa Jîn-bîn Liân-bêngSaa1 Baa1 Jan4 Man4 Lyun4 Mang4Shābā rénmín liánméngAbbreviationGRSPresidentGRS Presidential Council (MPGRS)[1](Officially in 2022)ChairmanHajiji NoorSecretary-GeneralMasidi ManjunDeputy ChairmanMaximus OngkiliJeffrey KitinganYong Teck LeePandikar Amin MuliaFounder…
هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (نوفمبر 2016) تاريخيًا كان حق الأجانب في التصويت في الولايات المتحدة قضية مثيرة للجدل.[1][2] الأجنبيّ، في هذا السياق، هو الشخص الغريب عن الولايات المتحدة أو ليس مواط…
Spa Presbyterian Church, November 2010 Spa is a small village in County Down, Northern Ireland, close to Ballynahinch. It is situated in the Down District Council area. Spa also has a small primary school which, in recent years, has had to expand to accommodate the increasing number of pupils resulting from the development of the new housing estates. It also has an Orange Hall. There is a lake just outside the village. History Spa was found to have a mineral spring sometime in the late 17th cent…
Kepulauan kutub Svalbard pertama kali ditemukan oleh Willem Barentsz pada tahun 1596, meskipun terdapat bukti sengketa penggunaan oleh Pomors atau suku Nordik. Perburuan paus-paus bowhead dimulai pada tahun 1611, yang didominasi oleh perusahaan Inggris dan Belanda, dan negara-negara lain yang juga berpartisipasi. Saat itu belum ada kesepakatan mengenai kedaulatan. Stasiun perburuan paus, yang terbesar adalah Smeerenburg yang dibangun pada abad ke-17. Secara bertahap perburuan paus menurun. Perbu…
Indian politician M. Ayyakkannu M. Ayyakkannu (born 15 August 1927) was an Indian politician. He was born in Ladapuram village, Trichinopoly District.[1][2] He was the son of S. Muthusamy.[1] After studied at Annamalai University in Chidambaram and the Madras Law College, obtained a B.A. (Honours) degree.[1][2] In 1949 he became the secretary of the Social Service League at Annamalai University, and became chairman of the History and Politics Association i…
Castle in Tokyo, Japan Setagaya Castle世田谷城Setagaya, Tokyo, Japan Setagaya CastleTypeHirajiro-style castleSite informationOwnerKira clan, Later Hōjō clanConditionruinsSite historyBuiltŌei PeriodBuilt byKira clanDemolished1590 Setagaya Castle (世田谷城, Setagaya-jō) is the remains of a castle structure in Setagaya, Tokyo, Japan. Its ruins have been protected as a Prefectural Historic Sites.[1][2] It is believed that the castle was constructed by the Kira clan i…
Artist discography Ciara discographyCiara performing during her debut tour Ciara: Live in Concert in November 2006Studio albums7EPs1Singles54 American singer Ciara has released seven studio albums, one extended play, one DVD, one promotional single, 54 singles (which includes 13 as a featured artist) and 28 music videos, including seven as a featured artist. She made her debut in 2004 with her debut album Goodies which debuted at three in the US and charted within the top 40 in several internati…
Indian political activist (born 1952) In this Indian name, the name Subbiah is a patronymic, and the person should be referred to by the given name, Veerapandian or the abbreviation Subavee. Suba VeerapandianChairperson ofSocial Justice Monitoring Committee of Tamil NaduIncumbentAssumed office 22 October 2021Member of the Advisory Committee for Tamil Nadu Text Book and Educational Services CorporationIncumbentAssumed office 27 July 2021General Secretary ofDravida Iyyakka Tamilar PeravaiI…
Baba PadmanjiBornBaba Padmanji Mule1831 (1831)BelgaumDied29 August 1906(1906-08-29) (aged 74–75)BombayOccupationWriterLanguageMarathiNationalityIndianGenreNovel, Poetry, ProseSubjectChristianity Baba Padmanji Mule, better known as Baba Padmanji (1831 - 29 August 1906) was an Indian writer, novelist, religious preacher and Protestant Christian reformer in the 19th-century Bombay Presidency, who is known for contributing to Marathi literature.[1] He is known for converting to C…
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Dragonfire video game – news · newspapers · books · scholar · JSTOR (July 2015) (Learn how and when to remove this template message) 1982 video gameDragonfireIntellivision box artDeveloper(s)ImagicPublisher(s)ImagicDesigner(s)Bob Smith[1]Platform(s)At…
Индуктивность L {\displaystyle L} Размерность L2MT−2I−2 Единицы измерения СИ Гн СГС см−1·с2 Классическая электродинамикаЭлектричество · Магнетизм Электростатика Закон Кулона Теорема Гаусса Электрический дипольный момент Электрический заряд Электрическая индукция Электрическо…
Aku Tidak Bisa BerpalingPembuatTriwarsanaPemeranKriss Hatta Ardina Rasti Adhitya PutriNegara asalIndonesiaBahasa asliIndonesiaJmlh. episode13 (sampai 17 Juli 2016) (daftar episode)ProduksiProduserHelmy YahyaDurasi60 menitSabtu, 22:15-23:15 WIB (5-19 Maret 2016)Jumat, 15:00-16:00 WIB (1-15 April 2016)Jumat, 15:30-16:30 WIB (22-29 April 2016, 13 Mei 2016)Sabtu, 16:00-17:00 WIB (28 Mei 2016)Minggu, 22:45-23:45 (17 Juli-11 September 2016)Rumah produksiIndonesiaRilis asliRilisSabtu, 5 Maret 2016 …
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