In the early 1920s, T. F. Jackson opened a two-room clinic on the second floor of the Touchton building in Dade City, Florida.[2][3] In late October 1926, he purchased the former house of Reverend H. N. Abraham for his practice.[2] He later moved it again several years later to a building west of Pasco Middle School.[2] On August 1, 1934, Pasco County, Florida purchased the facility and renamed it Jackson Memorial Hospital, in remembrance of the founder who died the same year.[2][4] Over the years several wings were added. In 1961, the older portion of the hospital was demolished.[2]
In 1981, Adventist Health System Sunbelt Healthcare Corporation purchased the hospital.[2][3] In January 1985, it was moved to Zephyrhills and was renamed East Pasco Medical Center.[3][4] The property in Dade City was purchased by the county for its health department, later the social services department and the Sheriff's Office also moved into the former medical facility.[2][4][5]
In 1999, East Pasco Medical Center expanded its emergency department, before it was expanded the hospital rejected patients, forcing them to go to Columbia Dade City Hospital.[6][7]
On January 1, 2006, East Pasco Medical Center rebranded to Florida Hospital Zephyrhills.[8]
On January 2, 2019, Florida Hospital Zephyrhills rebranded to AdventHealth Zephyrhills.[9][10]
On January 1, 2021, all hospitals were required to have their chargemaster on its website by the Centers for Medicare & Medicaid Services.[11] In a survey done in 2022, the majority of hospitals in Florida including AdventHealth Zephyrhills had failed to comply with the Hospital Price Transparency Law.[11][12] It was not until early February 2023, that the hospital was in full compliance with the law.[13]