ADP-dependent NAD(P)H-hydrate dehydratase (EC 4.2.1.136, (6S)-β-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing), (6S)-6-β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing, NADH-forming)) is an enzyme with systematic name (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming).^[1] This enzyme catalyses the following chemical reaction

(1) ADP + (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide ${\displaystyle \rightleftharpoons }$ AMP + phosphate + NADH

(2) ADP + (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate ${\displaystyle \rightleftharpoons }$ AMP + phosphate + NADPH

This enzyme acts equally well on hydrated NADH and hydrated NADPH.

• ADP-dependent+NAD(P)H-hydrate+dehydratase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)