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ABCG1
Identifiers
Aliases	ABCG1, ABC8, WHITE1, ATP binding cassette subfamily G member 1
External IDs	OMIM: 603076; MGI: 107704; HomoloGene: 21022; GeneCards: ABCG1; OMA:ABCG1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,297,244 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,336,962 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; jejunal mucosa; ; left adrenal cortex; ; spleen; ; Skeletal muscle tissue of rectus abdominis; ; lower lobe of lung; ; amniotic fluid; ; internal globus pallidus;
	Top expressed in
	globus pallidus; ; right lung lobe; ; olfactory tubercle; ; stria vascularis; ; dorsal striatum; ; medial dorsal nucleus; ; median eminence; ; arcuate nucleus; ; olfactory epithelium; ; lateral geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein dimerization activity; protein homodimerization activity; ADP binding; phospholipid transporter activity; ABC-type sterol transporter activity; cholesterol binding; ATPase activity; toxin transmembrane transporter activity; protein binding; protein heterodimerization activity; phospholipid binding; ATP binding; cholesterol transfer activity; ATPase-coupled transmembrane transporter activity;
Cellular component	integral component of membrane; recycling endosome; endosome; Golgi apparatus; endoplasmic reticulum membrane; membrane; Golgi membrane; plasma membrane; integral component of plasma membrane; endoplasmic reticulum; mitochondrion; external side of plasma membrane;
Biological process	phospholipid homeostasis; lipid transport; regulation of transcription, DNA-templated; detection of hormone stimulus; phospholipid efflux; glycoprotein transport; cholesterol transport; cholesterol metabolic process; response to organic substance; negative regulation of cholesterol storage; response to lipid; intracellular cholesterol transport; low-density lipoprotein particle remodeling; positive regulation of cholesterol efflux; transmembrane transport; cholesterol efflux; positive regulation of cholesterol biosynthetic process; negative regulation of lipid storage; cholesterol homeostasis; regulation of cholesterol esterification; negative regulation of macrophage derived foam cell differentiation; amyloid precursor protein catabolic process; reverse cholesterol transport; toxin transport; high-density lipoprotein particle remodeling; transport; cellular response to high density lipoprotein particle stimulus; positive regulation of protein secretion; positive regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
Orthologs
	9619
	11307
	ENSG00000160179
	ENSMUSG00000024030
	P45844
	Q64343
NM_004915; NM_016818; NM_207174; NM_207627; NM_207628;
	NM_207629; NM_207630
	NM_009593
NP_004906; NP_058198; NP_997057; NP_997510; NP_997511;
	NP_997512
	NP_033723
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene.^[5]^[6]^[7] It is a homolog of the well-known Drosophila gene white.

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily (subfamily G). It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.^[7]