AADACL2Arylacetamide Deacetylase Like 2, also known as AADACL2, is a protein which in humans is encoded by the AADACL2 gene. GeneThe AADACL2 gene consists of 27413 nucleotides[1] with an mRNA of approximately 5060 base pairs.[2] There are five exons found in the AADACL2 gene.[2] AADACL2 is found to function in catalytic activity, hydrolase activity, and found to enable carboxylic ester hydrolase activity.[3] mRNAThe chromosomal band location of AADACL2 is 3q25.1[4] and is located on the plus strand of the DNA. ProteinAADACL2 in humans is 401 amino acids long.[5] with a predicted molecular weight of 46 kDa.[6] The isoelectric point of AADACL2 is 7.2.[7] The AADACL2 protein contains two domains, Abhydrolase_3, that spans nearly the entire protein. Along with an intermediate domain which is Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole.[5] Both of which are found to be conserved amongst orthologs.  LocalizationHuman AADACL2 is predicted to be localized in the endoplasmic reticulum.[8] ExpressionAADACL2 is tissue specific. AADACL2 is expressed at a very high level in skin tissues.[4] It is found to express at low levels in placenta, esophagus, small intestine and colon.[4] It is also found in circular RNA induction during fetal development at higher levels at the intestines at 10 weeks and 20 weeks.[4] Tertiary structureThe protein AADACL2 was found to be composed of both alpha helices along with beta barrels.[9] EvolutionThe protein encoded by AADACL2[5] evolves slower than the fibrinogen alpha[10] protein but faster than the protein cytochrome c.[11] .png) ParalogsParalogs of AADACL2 include: AADAC (Arylacetamide Deacetylase), NCEH1 (Neutral Cholesterol Ester Hydrolase 1), AADACL3 (Arylacetamide Deacetylase Like 3), AADACL4 (Arylacetamide Deacetylase Like 4), and AFMID (Arylformamidase).[3] OrthologsArylacetamide Deacetylase like 2 is found only in mammals. AADACL2 is not found in fish, birds, reptiles, and amphibians. Arylacetamide Deacetylase like 2 is found in the following mammals: primates, flying lemurs, bats, rabbits & hares, rodents, insectivores, afrotheria, carnivores, even-toed ungulates, and odd-toed ungulates. Arylacetamide Deacetylase like 2 was approximately found to have first appeared in afrotheria 99 million years ago.
Clinical significanceAllergic contact dermatitis exposed to a nickel allergy, indicates that there is lower presence in the AADACL2 RNA when exposed to a nickel allergy versus the non-allergic control.[12] Arylacetamide deacetylase-like 2 was found to be in the top fifty skin enriched genes, and was predicted to contain a signal peptide and function as a secreted protein.[13] Resources
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