23S rRNA (cytidine2498-2'-O)-methyltransferase (EC2.1.1.186, YgdE, rRNA large subunit methyltransferase M, RlmM) is an enzyme with systematic nameS-adenosyl-L-methionine:23S rRNA (cytidine2498-2'-O-)-methyltransferase.[1] This enzyme catalyses the following chemical reaction