Mixed doubles
2022 US Open
Final
Champions	Storm Sanders John Peers
Runners-up	Kirsten Flipkens Édouard Roger-Vasselin
Score	4–6, 6–4, [10–7]
Events
Singles men women boys girls Doubles men women mixed boys girls WC Singles men women quad WC Doubles men women quad Legends men women mixed
← 2021 · US Open · 2023 →

Storm Sanders and John Peers defeated Kirsten Flipkens and Édouard Roger-Vasselin in the final, 4–6, 6–4, [10–7] to win the mixed doubles tennis title at the 2022 US Open.

Desirae Krawczyk and Joe Salisbury were the reigning champions,^[1] but Salisbury did not participate this year. Krawczyk partnered Neal Skupski, but lost in the second round to Caty McNally and William Blumberg.

	Semifinals							Final
	WC	Caty McNally William Blumberg	2	77	[8]
	4	Storm Sanders John Peers	6	65	[10]
								4	Storm Sanders John Peers	4	6	[10]
								PR	Kirsten Flipkens Édouard Roger-Vasselin	6	4	[7]
	PR	Kirsten Flipkens Édouard Roger-Vasselin	6	5	[10]
	2	Zhang Shuai Mate Pavić	4	7	[6]

	First round							Second round							Quarterfinals							Semifinals
	1	D Krawczyk N Skupski	77	6
	WC	A Parks C Eubanks	64	2				1	D Krawczyk N Skupski	2	4
	WC	C McNally W Blumberg	7	7				WC	C McNally W Blumberg	6	6
		V Azarenka T Kokkinakis	5	5											WC	C McNally W Blumberg	710	6
		J Ostapenko D Vega Hernández	6	77												J Ostapenko D Vega Hernández	68	2
		L Kichenok R Matos	2	65					J Ostapenko D Vega Hernández	6	6
		L Siegemund J Murray	2	65				7	E Perez M Venus	1	1
	7	E Perez M Venus	6	77																		WC	C McNally W Blumberg	2	77	[8]
	4	S Sanders J Peers	6	7																		4	S Sanders J Peers	6	65	[10]
	WC	C Harrison R Galloway	3	5				4	S Sanders J Peers	6	6
	WC	B Pera J Withrow	5	77	[11]			WC	B Pera J Withrow	4	4
		A Guarachi H Heliövaara	7	62	[9]										4	S Sanders J Peers	7	77
		L Fernandez J Sock	6	2	[10]											L Fernandez J Sock	5	63
		K Zimmermann T Pütz	2	6	[5]				L Fernandez J Sock	6	77
		G Dabrowski M Purcell	7	7					G Dabrowski M Purcell	4	64
	6	Z Yang R Bopanna	5	5

	First round							Second round							Quarterfinals							Semifinals
	5	J Pegula A Krajicek	7	6
	WC	R Montgomery N Monroe	5	4				5	J Pegula A Krajicek	64	4
		S Stosur M Ebden	6	6					S Stosur M Ebden	77	6
		A Klepač S González	3	3												S Stosur M Ebden	79	4	[9]
		N Melichar-Martinez K Krawietz	77	77											PR	K Flipkens É Roger-Vasselin	67	6	[11]
	Alt	E Routliffe A Mies	62	64					N Melichar-Martinez K Krawietz	63	65
	PR	K Flipkens É Roger-Vasselin	6	6				PR	K Flipkens É Roger-Vasselin	77	77
	3	G Olmos M Arévalo	4	4																		PR	K Flipkens É Roger-Vasselin	6	5	[10]
	8	D Schuurs M Middelkoop	4	4																		2	S Zhang M Pavić	4	7	[6]
	PR	L Hradecká Ł Kubot	6	6				PR	L Hradecká Ł Kubot	3	4
	PR	E Shibahara F Škugor	7	2	[10]			PR	E Shibahara F Škugor	6	6
		K Mladenovic N Mektić	5	6	[5]										PR	E Shibahara F Škugor	65	6	[3]
	WC	J Daniel R Ciamarra	4	2											2	S Zhang M Pavić	77	4	[10]
	WC	M Keys B Fratangelo	6	6				WC	M Keys B Fratangelo	4	2
	WC	L Chirico B Klahn	61	3				2	S Zhang M Pavić	6	6
	2	S Zhang M Pavić	77	6

• Alizé Cornet / Nicolas Mahut → replaced by Erin Routliffe / Andreas Mies

• Main draw