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Alexander Bublik defeated Alexander Zverev in the final, 6–4, 6–3 to win the singles title at the 2022 Open Sud de France. It was his maiden ATP Tour title.

David Goffin was the defending champion,^[1] but lost to Adrian Mannarino in the second round.

Singles
2022 Open Sud de France
Final
Champion	Alexander Bublik
Runner-up	Alexander Zverev
Score	6–4, 6–3
Details
Draw	28 (4Q, 3WC)
Seeds	8
Events
Singles Doubles
← 2021 · Open Sud de France · 2023 →

The top four seeds received a bye into the second round.

	Semifinals							Final
	1/WC	Alexander Zverev	6	6
		Mikael Ymer	1	3
								1/WC	Alexander Zverev	4	3
								6	Alexander Bublik	6	6
	5	Filip Krajinović	4	2
	6	Alexander Bublik	6	6

	First round							Second round							Quarterfinals							Semifinals
								1/WC	A Zverev	6	77
		I Ivashka	3	62					M McDonald	2	65
		M McDonald	6	77											1/WC	A Zverev	6	6
		A Davidovich Fokina	2	4												A Mannarino	1	0
		A Mannarino	6	6					A Mannarino	6	6
		B Bonzi	6	5	1			8/WC	D Goffin	4	2
	8/WC	D Goffin	2	7	6																	1/WC	A Zverev	6	6
																							M Ymer	1	3
								3	G Monfils	1	2
		C Moutet	65	4					M Ymer	6	6
		M Ymer	77	6												M Ymer	7	66	6
		H Gaston	2	1												R Gasquet	5	78	1
		S-w Kwon	6	6					S-w Kwon	5	4
		R Gasquet	63	6	6				R Gasquet	7	6
	7	U Humbert	77	4	3

	First round							Second round							Quarterfinals							Semifinals
	5	F Krajinović	7	77
		A Popyrin	5	63				5	F Krajinović	6	77
	PR	J-W Tsonga	6	6				PR	J-W Tsonga	4	62
	Q	K Żuk	4	4											5	F Krajinović	7	6
		A Molčan	65	0											Q	D Džumhur	5	2
	Q	D Džumhur	77	6				Q	D Džumhur	6	5	6
								4	N Basilashvili	1	7	2
																						5	F Krajinović	4	2
	6	A Bublik	77	77																		6	A Bublik	6	6
		T Griekspoor	64	65				6	A Bublik	6	62	6
	Q	P-H Herbert	7	6				Q	P-H Herbert	3	77	2
		P Gojowczyk	5	2											6	A Bublik	6	2	77
	WC	L Pouille	64	7	4										2	R Bautista Agut	4	6	64
	Q	G Simon	77	5	6			Q	G Simon	4	2r
								2	R Bautista Agut	6	3

	First round							Qualifying competition
	1	Henri Laaksonen	2	6	3
		Kacper Żuk	6	1	6
									Kacper Żuk	6	64	7
								6	Roman Safiullin	4	77	5
	WC	Luca Van Assche	1	1
	6	Roman Safiullin	6	6

	First round							Qualifying competition
	2	Feliciano López	1	4
	Alt	Ernests Gulbis	6	6
								Alt	Ernests Gulbis	64	2
								8	Damir Džumhur	77	6
		Zizou Bergs	5	2
	8	Damir Džumhur	7	6

	First round							Qualifying competition
	3	Pierre-Hugues Herbert	4	6	6
	WC	Sascha Gueymard Wayenburg	6	3	2
								3	Pierre-Hugues Herbert	77	7
									Mikhail Kukushkin	63	5
		Mikhail Kukushkin	6	6
	5	Jiří Lehečka	2	3

	First round							Qualifying competition
	4	Gilles Simon	79	79
		Marc-Andrea Hüsler	67	67
								4	Gilles Simon	6	7
								Alt	Antoine Hoang	4	5
	Alt	Lukáš Lacko	66	2
	Alt	Antoine Hoang	78	6

• Main draw
• Qualifying draw