Wheelchair men's singles
2021 US Open
Final
Champion	Shingo Kunieda
Runner-up	Alfie Hewett
Score	6–1, 6–4
Events
Singles men women boys girls Doubles men women mixed boys girls WC Singles men women quad WC Doubles men women quad Legends men women mixed
← 2020 · US Open · 2022 →

Defending champion Shingo Kunieda^[1] defeated Alfie Hewett in the final, 6–1, 6–4 to win the men's singles wheelchair tennis title at the 2021 US Open.^{[citation needed]} It was his eighth US Open singles title and 25th major singles title overall.

	Quarterfinals							Semifinals							Final
	1	Shingo Kunieda	6	6
	WC	Casey Ratzlaff	1	0
								1	Shingo Kunieda	4	6	6
									Gordon Reid	6	4	2
		Tom Egberink	1	4
		Gordon Reid	6	6
															1	Shingo Kunieda	6	6
															2	Alfie Hewett	1	4
		Stéphane Houdet	4	3
		Gustavo Fernández	6	6
									Gustavo Fernández	2	4
								2	Alfie Hewett	6	6
		Nicolas Peifer	5	2
	2	Alfie Hewett	7	6

• Draw