Dylan Alcott defeated the defending champion David Wagner in the final, 7–5, 6–2 to win the quad singles wheelchair tennis title at the 2018 US Open.
Standings are determined by: 1. number of wins; 2. number of matches; 3. in two-players-ties, head-to-head records; 4. in three-players-ties, percentage of sets won, or of games won; 5. steering-committee decision.