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The 1980 United States House of Representatives elections in South Carolina were held on November 4, 1980, to select six Representatives for two-year terms from the state of South Carolina. The primary elections for the Democrats and the Republicans were held on June 10 and the runoff elections were held two weeks later on June 24. Three incumbents were re-elected, but John Jenrette of the 6th congressional district was defeated in his bid for re-election and the open seat in the 1st congressional district was taken by the Republicans from the Democrats. The composition of the state delegation after the elections was four Republicans and two Democrats.

1st congressional district

Incumbent Democratic Congressman Mendel Jackson Davis of the 1st congressional district, in office since 1971, opted to retire. Tommy Hartnett, a Republican state senator from Charleston, defeated Thomas G. Moore in the Republican primary and Democrat Charles D. Ravenel in the general election.

Democratic primary

Democratic primary
Candidate	Votes	%
Charles D. Ravenel	30,966	55.6
Wheeler Tillman	17,070	30.7
Charles B. Brassell	3,838	6.9
Benjamin Frazier, Jr.	3,786	6.8

Republican primary

Republican primary
Candidate	Votes	%
Thomas F. Hartnett	10,510	75.4
Thomas G. Moore	3,428	24.6

General election results

South Carolina's 1st congressional district election results, 1980
Party		Candidate	Votes	%	±%
	Republican	Thomas F. Hartnett	81,988	51.6	+12.2
	Democratic	Charles D. Ravenel	76,963	48.4	−12.2
	No party	Write-Ins	10	0.0	0.0
Majority			5,025	3.2	−18.0
Turnout			158,961
	Republican gain from Democratic

2nd congressional district

Incumbent Republican Congressman Floyd Spence of the 2nd congressional district, in office since 1971, defeated Democratic challenger Tom Turnipseed.

Democratic primary

Democratic primary
Candidate	Votes	%
Tom Turnipseed	28,490	71.6
Leigh J. Leventis	11,303	28.4

General election results

South Carolina's 2nd congressional district election results, 1980
Party		Candidate	Votes	%	±%
	Republican	Floyd Spence (incumbent)	92,306	55.7	−1.6
	Democratic	Tom Turnipseed	73,353	44.3	+1.6
	No party	Write-Ins	19	0.0	0.0
Majority			18,953	11.4	−3.2
Turnout			165,678
	Republican hold

3rd congressional district

Incumbent Democratic Congressman Butler Derrick of the 3rd congressional district, in office since 1975, defeated Republican challenger Marshall Parker.

General election results

South Carolina's 3rd congressional district election results, 1980
Party		Candidate	Votes	%	±%
	Democratic	Butler Derrick (incumbent)	87,680	59.8	−22.1
	Republican	Marshall Parker	57,840	39.4	+21.3
	Libertarian	Boyce Lee Muller	1,118	0.8	+0.8
	No party	Write-Ins	4	0.0	0.0
Majority			29,840	20.4	−43.4
Turnout			146,642
	Democratic hold

4th congressional district

Incumbent Republican Congressman Carroll A. Campbell, Jr. of the 4th congressional district, in office since 1979, defeated Libertarian challenger Thomas P. Waldenfels.

General election results

South Carolina's 4th congressional district election results, 1980
Party		Candidate	Votes	%	±%
	Republican	Carroll Campbell (incumbent)	90,941	92.6	+40.5
	Libertarian	Thomas P. Waldenfels	6,984	7.1	+7.1
	No party	Write-Ins	248	0.3	+0.3
Majority			83,957	85.5	+79.6
Turnout			98,173
	Republican hold

5th congressional district

Incumbent Democratic Congressman Kenneth Lamar Holland of the 5th congressional district, in office since 1975, defeated Libertarian challenger Thomas Campbell.

General election results

South Carolina's 5th congressional district election results, 1980
Party		Candidate	Votes	%	±%
	Democratic	Ken Holland (incumbent)	99,773	87.5	+4.9
	Libertarian	Thomas Campbell	14,252	12.5	+12.5
	No party	Write-Ins	13	0.0	−0.2
Majority			85,521	75.0	−9.6
Turnout			114,038
	Democratic hold

6th congressional district

Incumbent Democratic Congressman John Jenrette of the 6th congressional district, in office since 1975, was defeated in his bid for re-election by Republican John Light Napier.

Democratic primary

Democratic primary
Candidate	Votes	%
John Jenrette	38,565	45.3
Hicks Harwell	22,251	26.2
John W. Brassington	11,346	13.3
Erick B. Ficken	8,061	9.5
William T. McElveen, Sr.	4,887	5.7

Democratic primary runoff
Candidate	Votes	%	±%
John Jenrette	42,759	52.5	+7.3
Hicks Harwell	38,621	47.5	+21.3

Republican primary

Republican primary
Candidate	Votes	%
John Light Napier	3,735	60.0
Edward Lunn Young	2,491	40.0

General election results

South Carolina's 6th congressional district election results, 1980
Party		Candidate	Votes	%	±%
	Republican	John Light Napier	75,635	51.7	+51.7
	Democratic	John Jenrette (incumbent)	70,445	48.2	−51.5
	No party	Write-Ins	86	0.1	−0.2
Majority			5,190	3.5	−95.9
Turnout			146,166
	Republican gain from Democratic