Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Leading Role er en award, givet af Screen Actors Guild for at ære den flotteste skuespiller-præsentation, som kvindelige hovedrolle i en film.
Vindere og nominerede
1990'erne
1994 – Jodie Foster – Nell
1995 – Susan Sarandon – Dead Man Walking
Meryl Streep – The Bridges of Madison County
Elisabeth Shue – Leaving Las Vegas
Emma Thompson – Sense and Sensibility
Joan Allen – Nixon
1996 – Frances McDormand – Fargo
Kristin Scott Thomas – The English Patient
Diane Keaton – Marvin's Room
Brenda Blethyn – Secrets & Lies
Gena Rowlands – Unhook the Stars
1997 – Helen Hunt – As Good as It Gets
1998 – Gwyneth Paltrow – Shakespeare in Love
1999: Annette Bening – American Beauty
2000'erne
2000 – Julia Roberts – Erin Brockovich
2001 – Halle Berry – Monster's Ball
2002 – Renée Zellweger – Chicago
2003 – Charlize Theron – Monster
2004 – Hilary Swank – Million Dollar Baby
Annette Bening – Being Julia
Kate Winslet – Eternal Sunshine of the Spotless Mind
Imelda Staunton – Vera Drake
Catalina Sandino Moreno – Maria, eres llena de gracia (Maria Full of Grace)
2005 – Reese Witherspoon – Walk the Line
2006 – Helen Mirren – The Queen
2007 – Julie Christie – Away From Her
2008: – Meryl Streep – Doubt
2009 – Sandra Bullock – The Blind Side
2010'erne
2010 – Natalie Portman – Black Swan som Nina Sayers/Svanedronningen
2011 – Viola Davis – Niceville som Aibileen Clark
Life Achievement Award Film Fjernsyn Ceremonier (året, hvor filmene havde premiere; ceremonien finder sted året efter)