12th Annual Screen Actors Guild Awards uddeling, for at ære de bedste TV- og filmskuespillere for året 2005, blev afholdt den 29. januar 2006 i Los Angeles Shrine Exposition Center, i Los Angeles, Californien. Dette var det 10. år i træk, at uddelingen blev afholdt centeret.^[1]

I blandt de nominerede for film priserne var det Brokeback Mountain der fik flest nomineringer med i alt 4. Filmen Capote og Crash fik den næsthøjeste antal nomineriner med 3 hver. Ingen film vandt dog mere end én award. Fjernsyn-kategoriererne var det mini-serien Empire Falls og spin-off seriesnBoston Legal som hver fik 2 nomineringer. Desperate Housewives var den eneste TV-serie, der vandt mere end én award, den fik nemlig to.

Screen Actors Guild Life Achievement Award gik til den tidligere børneskuespiller Shirley Temple Black^[2]

Philip Seymour Hoffman – Capote

• Russell Crowe – Cinderella Man
• Heath Ledger – Brokeback Mountain
• Joaquin Phoenix – Walk the Line
• David Strathairn – Good Night, and Good Luck

Reese Witherspoon – Walk the Line

• Judi Dench – Mrs. Henderson Presents
• Felicity Huffman – Transamerica
• Charlize Theron – North Country
• Ziyi Zhang – Memoirs of a Geisha

Paul Giamatti – Cinderella Man

• Don Cheadle – Crash
• George Clooney – Syriana
• Matt Dillon – Crash
• Jake Gyllenhaal – Brokeback Mountain

Rachel Weisz – The Constant Gardener

• Amy Adams – Junebug
• Catherine Keener – Capote
• Frances McDormand – North Country
• Michelle Williams – Brokeback Mountain

Crash

Chris Bridges

Sandra Bullock

Don Cheadle

Matt Dillon

Jennifer Esposito

William Fichtner

Brendan Fraser

Terrence Howard

Thandie Newton

Ryan Phillippe

Larenz Tate

• Brokeback Mountain
• Capote
• Good Night, and Good Luck
• Hustle & Flow

Paul Newman – Empire Falls

• Kenneth Branagh – Warm Springs
• Ted Danson – Knights of the South Bronx
• Ed Harris – Empire Falls
• Christopher Plummer – Our Fathers

S. Epatha Merkerson – Lackawanna Blues

• Tonantzin Carmelo – Into The West
• Cynthia Nixon – Warm Springs
• Joanne Woodward – Empire Falls
• Robin Wright Penn – Empire Falls

Kiefer Sutherland – 24 timer

• Alan Alda – The West Wing
• Patrick Dempsey – Grey's Anatomy
• Hugh Laurie – House
• Ian McShane – Deadwood

Sandra Oh – Grey's Anatomy

• Patricia Arquette – Medium
• Geena Davis – Commander in Chief
• Mariska Hargitay – Law & Order: Special Victims Unit
• Kyra Sedgwick – The Closer

• Sean Hayes – Will & Grace
• Larry David – Curb Your Enthusiasm
• Jason Lee – My Name Is Earl
• William Shatner – Boston Legal
• James Spader – Boston Legal

• Felicity Huffman – Desperate Housewives
• Candice Bergen – Boston Legal
• Patricia Heaton – Everybody Loves Raymond
• Megan Mullally – Will & Grace
• Mary-Louise Parker – Weed

Lost

Adewale Akinnuoye-Agbaje

Naveen Andrews

Emilie de Ravin

Matthew Fox

Jorge Garcia

Maggie Grace

Josh Holloway

Malcolm David Kelley

Daniel Dae Kim

Yunjin Kim

Evangeline Lilly

Dominic Monaghan

Terry O'Quinn

Harold Perrineau

Michelle Rodriguez

Ian Somerhalder

Cynthia Watros

• Grey's Anatomy
• Six Feet Under
• The Closer
• The West Wing

Desperate Housewives

Roger Bart

Andrea Bowen

Mehcad Brooks

Ricardo Antonio Chavira

Marcia Cross

Steven Culp

James Denton

Teri Hatcher

Felicity Huffman

Brent Kinsman

Shane Kinsman

Eva Longoria

Mark Moses

Doug Savant

Nicolette Sheridan

Brenda Strong

Alfre Woodard

• Arrested Development
• Boston Legal
• Curb Your Enthusiasm
• Everybody Loves Raymond
• My Name Is Earl

Shirley Temple Black

• DigitalHit.com 12th Annual SAG Awards Photos Arkiveret 6. april 2008 hos Wayback Machine